Archive for ‘Academy of Military Medical Sciences’

09/04/2020

Coronavirus vaccine trials: Chinese volunteer in Wuhan tells his story

  • ‘I felt excited and proud of myself,’ says restaurant owner and former volunteer ambulance driver Xiang Yafei
  • ‘I didn’t feel afraid at all. In my mind, it’s already a successful vaccine,’ he says
Wuhan restaurant owner Xiang Yafei says he wasn’t afraid to be a coronavirus vaccine guinea pig. Photo: Handout
Wuhan restaurant owner Xiang Yafei says he wasn’t afraid to be a coronavirus vaccine guinea pig. Photo: Handout
With more than 1.5 million confirmed cases around the world and over 88,000 deaths, the race to develop a vaccine for the coronavirus is hotting up.
According to the World Health Organisation, about 35 companies and academic institutions are currently working on candidate products. Among the front-runners are China’s CanSino Biologics and Moderna Therapeutics in the United States, both of which have begun phase one clinical trials.
In China, those tests, which started on March 19, involve 108 volunteers from Wuhan, the city in which the virus that causes Covid-19 was first detected.
Among them is 30-year-old restaurant owner Xiang Yafei, who spoke to the South China Morning Post about his experiences so far.

Why did you apply to be a vaccine trial volunteer?

I had been doing various voluntary jobs since the end of January when Wuhan was put under lockdown. In the middle of March, one of my friends who knew about the vaccine study asked if I would be interested in joining.
At first I was afraid because there was uncertainty [about the vaccine]. I asked around and some of my friends said there was some risk to being a candidate as I’d be injected with some kinds of virus, but I felt better after I did some research about it online.
Before joining the clinical trials, Xiang worked as a volunteer ambulance driver. Photo: Handout
Before joining the clinical trials, Xiang worked as a volunteer ambulance driver. Photo: Handout
Also, because the vaccine was developed by the Academy of Military Medical Sciences [a research unit of the People’s Liberation Army] and CanSino, I thought its safety should be guaranteed, as I have confidence in the PLA because several of my relatives are former soldiers. So I agreed to join the trial but didn’t tell my parents because I didn’t want to worry them.

I went to the research team’s office on March 16 and filed my application – that was before they officially announced they were recruiting volunteers on the internet. While I was at the office, I was lucky to meet Major General Chen Wei, the team leader, who explained about the development of the vaccine and assured me that it wouldn’t damage my body. That boosted my confidence.

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When did you receive your injection and how did you feel at that time?

I was given mine on the morning of March 19 and immediately put into quarantine for 14 days at a PLA facility. My number in the volunteer group is 006, meaning I was the sixth person to get the vaccine. Before the injection, I underwent a strict physical check-up. I later learned that more than 5,200 people had applied to be volunteers.

Receiving the vaccine was no different to any other injection I’d had before in my life. I didn’t feel any pain and it only lasted about 10 seconds.

But in my heart, I felt excited and proud of myself. I understand that the vaccine will be an important part in battling this coronavirus and testing it is part of the preparations before it can be put on the market.

Xiang (right) said team leader Chen Wei (left) told him about the development of the vaccine and assured him he would come to no harm. Photo: Handout
Xiang (right) said team leader Chen Wei (left) told him about the development of the vaccine and assured him he would come to no harm. Photo: Handout
As volunteers, our job is to work together with the scientists. After all, academician Chen [the major general is also a member of the Chinese Academy of Engineering] and six members of her team have also been injected with the vaccine, and she was the first person to receive it.

They didn’t show any bad symptoms, so at that moment, I didn’t feel afraid at all. In my mind, it’s already a successful vaccine.

And how has your health been since receiving the vaccine?

I had a fever, 37.6 degrees, for the first two days. It was like catching a normal cold, with symptoms of fatigue and drowsiness. But from the third day, my condition improved and I was basically in good health.

The 108 volunteers are divided into three streams, with each receiving either a low, medium or high dose of the drug. I was in the low group so only got one dose. Volunteers in the medium group also got one and the high group were given two shots. As far as I know, everyone was fine after receiving their injections.

When will your trial result be available?

After my quarantine period ended on April 2, I was given a CAT scan and the researchers took a sample of my blood for testing. They said it would be two weeks before they could tell if there were coronavirus antibodies in my bloodstream.

I am not sure if they will tell me the result, but over the next five months I have to do four more blood tests to see if I have antibodies and how long they might remain in my blood.

What did you do to keep yourself entertained during the quarantine period?

It was just rest for me. Before then I’d been a volunteer ambulance driver in Wuhan, working every day taking coronavirus patients to hospital. I’d been really busy for more than a month, so the 14-day quarantine period gave me a chance to relax and catch up on some sleep.

I really enjoyed my time there thanks to the meals I was given, which were nutritious and varied.

The volunteers had to stay in their rooms and we were not allowed to visit each other. We were also told to check our temperature every day and to report any symptoms. I read books and exercised in my room. Some of the volunteers practised calligraphy, some played football with their toilet paper rolls, some jogged, some composed songs, and some made videos about their life in quarantine and uploaded the clips to social media. We did everything just in our own rooms.

Chinese firm CanSino Biologics is one of the front-runners in the race to develop a vaccine for the coronavirus. Photo: Handout
Chinese firm CanSino Biologics is one of the front-runners in the race to develop a vaccine for the coronavirus. Photo: Handout

So what was it like working as an ambulance driver?

It was a race against time trying to get people to hospital as quickly as I could. But I felt a real sense of purpose.

At first, I didn’t want to do such work. I was scared because all the patients had been confirmed or were suspected of being infected, and they were contagious.

I was told that no one wanted to be an ambulance driver, but I had a licence to drive a minivan so I decided to do it. I think we young people should make a contribution to society, especially during this difficult time and in our home city and home province, so I applied.

Also, [each day at work] I took a gourd with me. It is called hulu in Mandarin and has auspicious implications in Chinese, as hu sounds similar to fu, which means good luck.

How was your restaurant business affected by the epidemic?

I lost about half a million yuan (US$70,000) because of it. I decided to shut my restaurant down on January 21, two days before the official lockdown, because there had been rumours it was coming and I wanted my workers to be able to leave Wuhan and return to their hometowns.

Right now I’m making preparations to reopen my restaurant, which means a lot of cleaning and disinfecting, and thinking about serving all my customers again.

So how did you feel when the lockdown was lifted on Wednesday?

The situation in Wuhan is getting better. We are proud of what we did for this city. We hope the coronavirus cases can drop to zero soon and our lives can get back to normal.

Source: SCMP

18/03/2020

China developing 9 potential vaccines in global race for coronavirus cure

  • Company making front-runner appeals for people to take part in trial stage, which nine potential Chinese vaccines are set to enter in April
  • US trialling vaccine that copies virus’ genetic code, amid international search for a drug to help limit the outbreak’s human and economic impact
CanSino is recruiting healthy volunteers for a clinical trial of its vaccine candidate. Photo: Weibo
CanSino is recruiting healthy volunteers for a clinical trial of its vaccine candidate. Photo: Weibo
The race to develop a Covid-19 vaccine is on, with the United States already starting a clinical trial and China close behind.
On Tuesday, vaccine producer CanSino Biologics, in Tianjin in China’s northeast, said it was looking for volunteers to take part in a six-month clinical trial of a treatment it had developed jointly with the Academy of Military Medical Sciences.
“The vaccine does not contain infectious substances, is highly safe and stable, and requires only one inoculation,” the Hubei Centre for Disease Control and Prevention (CDC) said in its request for volunteers.
Its announcement came a day after the first participant began a phase I trial for an experimental vaccine funded by the US National Institutes of Health and developed by biotech startup Moderna.
Chinese scientists identify two major types of the new coronavirus in preliminary study

It uses messenger ribonucleic acid (mRNA) technology that copies the genetic code of the virus instead of the actual virus. To date, no mRNA vaccine has been approved for humans.

China’s own mRNA vaccine candidate, jointly developed by the Chinese Centre for Disease Control and Prevention, Tongji University and Stermina in Shanghai, is undergoing animal trials and is expected to enter the clinical phrase in mid-April.

Developed by the CanSino and the Academy of Military Medical Sciences, the vaccine is the front-runner of nine that China is developing. All are in the process of completing preclinical trial studies and will enter clinical trials in April, with some expected to advance faster than others, according to Wang Junzhi, a biological products quality control expert and academician with the Chinese Academy of Sciences.

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“China’s research and development of a vaccine for the coronavirus is, generally speaking, among the most advanced in the world,” Wang said at a press briefing in Beijing on Tuesday. “[We] will not be slower than other countries.”

Coronavirus: Scientists dismiss claim that humans engineered the deadly contagion

Hopes have been pinned on developing a vaccine, especially for vulnerable groups such as the elderly, in the face of an epidemic with no known cure that has brought the world to a partial standstill.

Scientists around the world are conducting experiments, and the US is reported to have tried to buy a Germany vaccine developer so that it would supply to the US only – with the German government reportedly offering its own financial incentives for the biopharmaceutical company concerned, CureVac, to stay in the country.

“A vaccine is the most effective medical means for epidemic prevention and control as it can effectively stop the spread of the virus,” Lei Chaozi, director of science and technology at China’s Ministry of Education, said.

“Vaccines also play an important part in … stabilising the economy and enabling the country to return to normal as work and production resume.”

Why did a ‘cured’ coronavirus patient die in China? His widow wants answers

7 Mar 2020

President Xi Jinping called for faster development of coronavirus vaccines and treatment drugs when he inspected the Academy of Military Medical Sciences two weeks ago.

About 1,000 Chinese scientists have been working on the push for vaccines, with nine vaccines developed through five different approaches, including an inactivated vaccine, a viral vector-based vaccine and a gene vaccine.

Wang said that the vaccines needed to satisfy strictly the relevant regulations and technical standards – as well as World Health Organisation requirements – before starting clinical trials.

The potential vaccine developed by CanSino and military researchers, led by virologist Chen Wei, is genetically engineered. “Spikes” on the surface of the coronavirus bind to human cells and enable the virus to invade the human cells, causing the sometimes fatal infection known as Covid-19. In theory, vaccines can rehearse such an attack and trigger the human body to be primed to respond to a real infection.

CanSino has submitted the pre-investigational new drug review application for the Ad5-nCoV vaccine to Chinese regulatory authorities, and is in the process of submitting the related technical documents.

According to the Hubei CDC, volunteers for the trial must be 18 to 60 years old with no history of coronavirus infection.

Source: SCMP

17/03/2020

China gives go-ahead for human trials of potential COVID-19 vaccine – state media

BEIJING (Reuters) – China has given the go-ahead for researchers to begin human safety tests of an experimental coronavirus vaccine in the race to develop a shot against the COVID-19 epidemic that has killed more than 7,000 people worldwide.

Researchers at China’s Academy of Military Medical Sciences, – affiliated to the Chinese People’s Liberation Army (PLA) -received approval to launch early-stage clinical trials of the potential vaccine starting this week, the ruling Communist Party’s People’s Daily reported on Tuesday.

Scientists in the United States said on Monday that clinical trials had begun for a vaccine developed by its National Institute of Allergy and Infectious Diseases and the U.S. biotech firm Moderna.

Details in the Chinese clinical trial registration database show that a “Phase 1” test that will examine whether experimental shot is safe in humans aims to recruit 108 healthy people to take part between March 16 and December 31.

The trial will be conducted by China’s Academy of Military Medical Sciences and the Hong Kong-listed biotech firm CanSino Biologics, the database showed.

Experts at the World Health Organization say they do not expect any fully tested and approved vaccine to reach the market until the middle of next year.

Source: Reuters

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