Archive for ‘humans’

02/05/2020

How a llama could hold the key to beating the coronavirus

  • An antibody engineered from the animal’s immune system was found to neutralise the virus that causes Covid-19
  • American and Belgian researchers hope the discovery may help protect humans from the deadly illness
Winter the lama (front) lives on a farm operated by Ghent University's Vlaams Institute for Biotechnology. Photo: Tim Coppens
Winter the llama (front) lives on a farm operated by Ghent University’s Vlaams Institute for Biotechnology. Photo: Tim Coppens

A Belgian llama could hold the key to producing an antibody that neutralises the coronavirus that causes Covid-19.

More studies and clinical trials are needed to see if it can be used in humans to treat Covid-19, but the team of American and Belgian scientists who engineered the antibody said they were encouraged by their preliminary findings, which will be published in the journal Cell next week.

Jason McLellan, from the University of Texas at Austin and co-author of the study, described it as one of the “first antibodies known to neutralise Sars-CoV-2”, the official name for the virus.

“With antibody therapies, you’re directly giving somebody the protective antibodies and so, immediately after treatment, they should be protected,” he wrote in a press release.

“The antibodies could also be used to treat somebody who is already sick to lessen the severity of the disease.”
Winter the llama produced antibodies that proved effective against the Sars-CoV-2 virus. Photo: Tim Coppens
Winter the llama produced antibodies that proved effective against the Sars-CoV-2 virus. Photo: Tim Coppens
The scientists have been working on coronaviruses – including severe acute respiratory syndrome (Sars) and Middle East respiratory syndrome (Mers) – for years.

In 2016 they injected the llama, named Winter, with Sars and Mers in the hope of developing a treatment for the diseases.

“I thought this would be a small side project,” said Dorien De Vlieger from Ghent University in Belgium, who helped to isolate antibodies against coronaviruses from the llamas.

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“Now the scientific impact of this project became bigger than I could ever expect. It’s amazing how unpredictable viruses can be.”

A llama’s immune system produces two types of antibodies when it detects pathogens, one similar to human antibodies and one that is about a quarter of the size.

The antibodies produced by Winter were found to be effective in targeting the Sars virus’s spike protein, which allows it to bind to human cells.

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This year they decided to test the antibodies Winter had produced during the Sars experiment to see if it could prove effective against Covid-19.

Although it did bind itself to the Sars-CoV-2 virus it did so “weakly”, so the team then linked two copies of the antibody together to make it bind more effectively.

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“That was exciting to me because I’d been working on this for years. But there wasn’t a big need for a coronavirus treatment then. This was just basic research,” said Daniel Wrapp from the University of Texas, a co-author of the study.

The smaller type of antibodies produced by llamas, called single-domain antibodies or nanobodies, can be used in an inhaler, according to Wrapp.

“That makes them potentially really interesting as a drug for a respiratory pathogen because you’re delivering it right to the site of infection,” said Wrapp.

Researchers created an antibody dubbed VHH-72Fc (blue) that binds tightly to the Sars-CoV-2 spike protein (pink, green and orange), blocking the virus from infecting cells. Photo: University of Texas at Austin
Researchers created an antibody dubbed VHH-72Fc (blue) that binds tightly to the Sars-CoV-2 spike protein (pink, green and orange), blocking the virus from infecting cells. Photo: University of Texas at Austin
The researchers are preparing for more trials with hamsters or primates to further test the antibody, before taking it to human trials.
The main subject of the study, Winter the llama, is now four years old and lives on a farm operated by Ghent University’s Vlaams Institute for Biotechnologym which said it has around 130 other llamas and alpacas at the facility.
Source: SCMP
02/04/2020

Shenzhen becomes first Chinese city to ban eating cats and dogs

A cat waiting to be adopted looks out of its cage at the Royal Society for the Prevention of Cruelty to Animals (RSPCA)Image copyright GETTY IMAGES
Image caption Most Chinese people don’t actually consume dogs and cats and never plan to

Shenzhen has become the first Chinese city to ban the sale and consumption of dog and cat meat.

It comes after the coronavirus outbreak was linked to wildlife meat, prompting Chinese authorities to ban the trade and consumption of wild animals.

Shenzhen went a step further, extending the ban to dogs and cats. The new law will come into force on 1 May.

Thirty million dogs a year are killed across Asia for meat, says Humane Society International (HSI).

However, the practice of eating dog meat in China is not that common – the majority of Chinese people have never done so and say don’t want to.

“Dogs and cats as pets have established a much closer relationship with humans than all other animals, and banning the consumption of dogs and cats and other pets is a common practice in developed countries and in Hong Kong and Taiwan,” the Shenzhen city government said, according to a Reuters report.

“This ban also responds to the demand and spirit of human civilization.”

Animal advocacy organisation HSI praised the move.

“This really could be a watershed moment in efforts to end this brutal trade that kills an estimated 10 million dogs and 4 million cats in China every year,” said Dr Peter Li, China policy specialist for HSI.

However, at the same time as this ruling, China approved the use of bear bile to treat coronavirus patients.

Bear bile – a digestive fluid drained from living captive bears – has long been used in traditional Chinese medicine.

The active ingredient, ursodeoxycholic acid, is used to dissolve gallstones and treat liver disease. But there is no proof that it is effective against the coronavirus and the process is painful and distressing for the animals

Brian Daly, a spokesman for the Animals Asia Foundation, told AFP: “We shouldn’t be relying on wildlife products like bear bile as the solution to combat a deadly virus that appears to have originated from wildlife.”

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A wildlife market

In February, Chinese authorities banned the trade and consumption of wild animals.

The move came after it emerged that a market in Wuhan selling wild animals and wildlife meat could have been the starting point for the outbreak of the new coronavirus, providing the means for the virus to travel from animals to humans.

News of this led the Chinese government to crack down strongly on the trade and on the markets that sold such products.

Covered market in ShenzhenImage copyright GETTY IMAGES
Image caption File photo of a wet market in China

There are now close to one million confirmed cases of the virus worldwide, and more than 47,000 deaths, according to a Johns Hopkins University tally.

In China alone, there are 81,589 confirmed cases and 3,318 deaths, said the National Health Commission.

Scientists and researchers are still no closer to finding out what the source of the virus is and how it could have spread to humans.

Source: The BBC

29/03/2020

Coronavirus: pathogen could have been spreading in humans for decades, study says

  • Virus may have jumped from animal to humans long before the first detection in Wuhan, according to research by an international team of scientists
  • Findings significantly reduce the possibility of the virus having a laboratory origin, director of the US National Institute of Health says
An international team of scientists say the coronavirus may have jumped from animal to humans long before the first detection in China. Photo: AP
An international team of scientists say the coronavirus may have jumped from animal to humans long before the first detection in China. Photo: AP
The coronavirus that causes Covid-19 might have been quietly spreading among humans for years or even decades before the sudden outbreak that sparked a global health crisis, according to an investigation by some of the world’s top virus hunters.
Researchers from the United States, Britain and Australia looked at piles of data released by scientists around the world for clues about the virus’ evolutionary past, and found it might have made the jump from animal to humans long before the first detection in the central China city of Wuhan.
Though there could be other possibilities, the scientists said the coronavirus carried a unique mutation that was not found in suspected animal hosts, but was likely to occur during repeated, small-cluster infections in humans.

The study, conducted by Kristian Andersen from the Scripps Research Institute in California, Andrew Rambaut from the University of Edinburgh in Scotland, Ian Lipkin from Columbia University in New York, Edward Holmes from the University of Sydney, and Robert Garry from Tulane University in New Orleans, was published in the scientific journal Nature Medicine on March 17.

Dr Francis Collins, director of the US National Institute of Health, who was not involved in the research, said the study suggested a possible scenario in which the coronavirus crossed from animals into humans before it became capable of causing disease in people.

“Then, as a result of gradual evolutionary changes over years or perhaps decades, the virus eventually gained the ability to spread from human to human and cause serious, often life-threatening disease,” he said in an article published on the institute’s website on Thursday.

In December, doctors in Wuhan began noticing a surge in the number of people suffering from a mysterious pneumonia. Tests for flu and other pathogens returned negative. An unknown strain was isolated, and a team from the Wuhan Institute of Virology led by Shi Zhengli traced its origin to a bat virus found in a mountain cave close to the China-Myanmar border.

The two viruses shared more than 96 per cent of their genes, but the bat virus could not infect humans. It lacked a spike protein to bind with receptors in human cells.

Coronaviruses with a similar spike protein were later discovered in Malayan pangolins
by separate teams from Guangzhou and Hong Kong, which led some researchers to believe that a recombination of genomes had occurred between the bat and pangolin viruses.
Doctors in Wuhan began noticing a surge in the number of people suffering from a mysterious pneumonia in December. Photo: Handout
Doctors in Wuhan began noticing a surge in the number of people suffering from a mysterious pneumonia in December. Photo: Handout
But the new strain, or SARS-Cov-2, had a mutation in its genes known as a polybasic cleavage site that was unseen in any coronaviruses found in bats or pangolins, according to Andersen and his colleagues.

This mutation, according to separate studies by researchers from China, France and the US, could produce a unique structure in the virus’ spike protein to interact with furin, a widely distributed enzyme in the human body. That could then trigger a fusion of the viral envelope and human cell membrane when they came into contact with one another.

Some human viruses including HIV and Ebola have the same furin-like cleavage site, which makes them contagious.

It is possible that the mutation happened naturally to the virus on animal hosts. Sars (severe acute respiratory syndrome) and Mers (Middle East respiratory syndrome), for instance, were believed to have been direct descendants of species found in masked civets and camels, which had a 99 per cent genetic similarity.

There was, however, no such direct evidence for the novel coronavirus, according to the international team. The gap between human and animal types was too large, they said, so they proposed another alternative.

“It is possible that a progenitor of SARS-CoV-2 jumped into humans, acquiring the genomic features described above through adaptation during undetected human-to-human transmission,” they said in the paper.

“Once acquired, these adaptations would enable the pandemic to take off and produce a sufficiently large cluster of cases to trigger the surveillance system that detected it.”

They said also that the most powerful computer models based on current knowledge about the coronavirus could not generate such a strange but highly efficient spike protein structure to bind with host cells.

The study had significantly reduced, if not ruled out, the possibility of a laboratory origin, Collins said.

“In fact, any bioengineer trying to design a coronavirus that threatened human health probably would never have chosen this particular conformation for a spike protein,” he said.

The findings by Western scientists echoed the mainstream opinion among Chinese researchers.

Zhong Nanshan, who advises Beijing on outbreak containment policies, had said on numerous occasions that there was growing scientific evidence to suggest the origin of the virus might not have been in China.

“The occurrence of Covid-19 in Wuhan does not mean it originated in Wuhan,” he said last week.

A doctor working in a public hospital treating Covid-19 patients in Beijing said numerous cases of mysterious pneumonia outbreaks had been reported by health professionals in several countries last year.

Re-examining the records and samples of these patients could reveal more clues about the history of this worsening pandemic, said the doctor, who asked not to be named due to the political sensitivity of the issue.

“There will be a day when the whole thing comes to light.”

Source: SCMP

24/01/2020

China shuts part of Great Wall as virus toll hits 26

BEIJING, China (Reuters) – China ramped up measures to contain a virus that has killed 26 people and infected more than 800, suspending public transport in 10 cities, shutting temples over the Lunar New Year and even closing the Forbidden City and part of the Great Wall.

The week-long holiday to welcome the Year of the Rat began on Friday, raising fears the infection rate could accelerate as hundreds of millions of people travel to their homes and abroad in what is usually a festive time of year.

The World Health Organisation (WHO) has declared the new coronavirus an emergency for China but stopped short of declaring the epidemic of international concern.

While most of the cases and all of the deaths have been in China, the virus has been detected in Thailand, Vietnam, Singapore, Japan, South Korea, Taiwan and the United States. It was likely Britain also had cases, a health official said.

The newly identified coronavirus has created alarm because it is too early to know just how dangerous it is and how easily it spreads between people.

Symptoms include fever, difficulty breathing and coughing.

Most of the fatalities have been elderly, many with pre-existing conditions, the WHO said.

Cases are likely to continue to rise in China but it is too soon to evaluate the severity of the virus, a WHO spokesman said on Friday.

As of Thursday, there were 830 confirmed cases and 26 people had died there, China’s National Health Commission said.

In Wuhan, where the outbreak began last month, pharmacies were running out of supplies and hospitals were flooded with nervous resident seeking medical checks.

“There’s so much news, so much data, every 10 minutes there’s an update, it’s frightening, especially for people like us in a severely hit area,” Lily Jin, 30, a resident of the city, told Reuters by phone.

GRAPHIC: The spread of a new coronavirus – here

Reuters Graphic

MORE RESTRICTIONS

While restrictions have already been put in place in cities across the country to curb the outbreak, China will take stricter and more targeted measures, state television reported citing a state council, or cabinet, meeting on Friday, but gave no further details.

“The spread of the virus has not been cut off … Local authorities should take more responsibility and have a stronger sense of urgency,” state broadcaster CCTV said.

Most cases have been in Wuhan, where the virus is believed to have originated in a market that traded illegally in wildlife. Preliminary research suggested it crossed to humans from snakes.

The city of 11 million people, and neighboring Huanggang, a city of about 7 million, were in virtual lockdown.

Nearly all flights at Wuhan’s airport had been canceled, and airports worldwide have stepped up the screening of passengers from China.

Checkpoints blocked the main roads leading out of town, and police checked incoming vehicles for wild animals.

Wuhan was rushing to build a 1,000-bed hospital for the infected by Monday, the official Changjiang Daily reported.

About 10 people got off a high-speed train that pulled into Wuhan on Friday afternoon but nobody got on before it resumed its journey. Although it stopped there, Wuhan had been removed from the train’s schedule.

“What choice do I have? It’s Chinese New Year. We have to see our family,” said a man getting off the train who gave his family name Hu.

CHINA EMERGENCY

The WHO said on Thursday it was a “bit too early” to designate the outbreak a public health emergency of international concern, which would require countries to step up their response.

Some experts believe the virus is not as dangerous as the one that caused the 2002-03 outbreak of Severe Acute Respiratory Syndrome, which also began in China and killed nearly 800 people, or the one that caused Middle East Respiratory Syndrome, which has killed more than 700 people since 2012.

There is no known vaccine or particular treatment.

“There is some work being done and there are some trials now for MERS (vaccines). And we may look at some point whether those treatments and vaccines would have some effect on this novel coronavirus,” WHO spokesman Tarik Jasarevic said on Friday.

Gilead Sciences Inc said it was assessing whether its experimental Ebola treatment could be used. Meanwhile, three research teams were starting work on vaccines, the Coalition for Epidemic Preparedness Innovations said.

In the meantime, Chinese authorities have imposed restrictions on movement and gatherings to try to stem the spread. It has advised people to avoid crowds and 10 cities in the central province of Hubei, where Wuhan is located, have suspended some transport, the Hubei Daily reported.

Some sections of the Great Wall near Beijing will be closed from Saturday, state media said.

Some temples have also closed, including Beijing’s Lama Temple where people make offerings for the new year, have also been closed as has the Forbidden City, the capital’s most famous tourist attraction.

Shanghai Disneyland will close from Saturday. The theme park has a 100,000 daily capacity and sold out during last year’s Lunar New Year holiday.

The virus is expected to dent China’s growth after months of economic worries over trade tensions with the United States, unnerving foreign companies doing business there.

Shares in luxury goods firms have suffered from the anticipated drop in demand from China, and on Friday French spirits group Remy Cointreau said it was “clearly concerned” about the potential impact.

Source: Reuters

19/09/2019

China to tap pork reserves as swine fever hits industry

 

A customer shops for pork at at butcher in ChinaImage copyright GETTY IMAGES

China is set to release pork supplies from its central reserves as it moves to tackle soaring prices and shortages caused by an outbreak of swine fever.

A state-backed body will auction 10,000 tonnes of frozen pork from its strategic reserves on Thursday.

China, the world’s biggest producer and consumer of pork, has struggled to control the spread of the disease.

Beijing has slaughtered more than 1 million pigs in a bid to contain the incurable pig virus.

The highly contagious disease is not dangerous to humans, but has hit China’s crucial pig-farming industry and driven up costs for consumers.

Pork prices jumped 46.7% in August on a year earlier, official figures showed.

In a bid to stabilise prices, a state-backed group that manages the pork reserves will auction imported frozen pork from countries including Denmark, France, the US and UK.

Only 300 tonnes will be sold to each bidder at the auction.

Pork is used widely in Chinese festivals, and the auction comes as the country prepares to celebrate a week-long national holiday for the 70th anniversary of the People’s Republic of China.

Julian Evans-Pritchard, senior China economist at Capital Economics, said the auction would provide slight relief to the industry but would not do much to contain prices.

“In itself, I don’t think it will be able to prevent pork prices from rising further unless they manage to get the disease under control,” he said.

Beijing created its strategic pork reserve in 2007 but the size of the stockpile is not known.

Capital Economics estimates that at most, the stockpile would hold four days’ worth of pork supplies to feed China.

How has swine fever hit China’s pork industry?

Pork is one of China’s main food staples and accounts for more than 60% of the country’s meat consumption. The industry produced close to 54 million tonnes of pork last year.

About 1.2 million pigs have been culled in China in an effort to halt the spread of swine fever since August 2018, according to data from the Food and Agriculture Organization, a UN agency.

In April, Rabobank estimated Chinese pork production would fall by up to 35% this year due to swine fever.

The supply shortage has sent pork prices soaring and has eaten into household incomes.

That poses a fresh challenge for the Chinese economy, which is already facing a slowdown and a trade war between Beijing and Washington.

Source: The BBC

18/08/2019

Chinese toys boom being fuelled by adult male consumers of collectibles

  • Adult consumers are fuelling a boom in China’s toy collectibles market
  • Men are spending thousands of dollars on figurines to express their identity, boost their street cred, and indulge their inner kid
Chinese collector Don Tang with artist Jason Freeny at the Jason Freeny X-Soul Station exhibition in Shanghai. Photo: Don Tang
Chinese collector Don Tang with artist Jason Freeny at the Jason Freeny X-Soul Station exhibition in Shanghai. Photo: Don Tang
Don Tang is proud of his toys. So much so that the Shanghai resident, 32, puts them on display both in his home and in the office of the company he runs.
And there are plenty to display. Tang, 32, has some 100 collectibles and the number is growing all the time. Each month he sets aside 2,000 yuan (US$280) to buy the top trending toys, newest releases, or one-of-a-kind items – either from physical stores, online or at toy conventions in China.

But the toys are not connected to his work as the CEO of a firm in the intellectual property sphere. They are simply a hobby, albeit one Tang takes seriously. The crowning jewel of his collection? A 6,000 yuan KAWS action figure bought in Tokyo, Japan.

“When I return home from work each day, I get to see [my toys] and it puts me in a good mood,” says Tang, who realises some people might not get the appeal of his hobby, but says it is an “addictive” pursuit and a way of appreciating designs and craftsmanship. Whether it’s SpongeBob SquarePants, Hello Kitty or Sesame Street, each toy has its own distinct, “lovable, cute, and personalised” identity, he says.
Remind you of someone? Hambuddha is a designer figurine made by Mighty Jaxx of Singapore that is aimed at the adult market. Photo: Mighty Jaxx
Remind you of someone? Hambuddha is a designer figurine made by Mighty Jaxx of Singapore that is aimed at the adult market. Photo: Mighty Jaxx

“When you look back at the toys that you collected at different times, you realise how your own aesthetic, tastes, and preferences have changed over time,” adds Tang, who would never dream of selling his precious collection.

Tang’s toy story is far from unique. Sales of toys and games in China – which produces 80 per cent of all the world’s toys – soared to 324 billion yuan in 2018, up from 135 billion yuan in 2013, according to market research company Euromonitor. Fuelling these sales is a growing army of toy connoisseurs just like Tang.

CASHING IN

Mighty Jaxx, a Singapore-based urban culture company that designs and manufactures collectibles and lifestyle products, is among the many companies benefiting from this surge in demand.

Its Chinese customer base accounts for 25 per cent of its projected revenue of S$10 million (US$7.21 million) for 2019 – and this proportion is expected to hit 40 per cent over the next few years, according to Mighty Jaxx’s founder and CEO, Jackson Aw, 30.

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An avid toy collector himself, Aw first mused over the idea of turning his hobby into a viable business back in 2012. He ventured to Shenzhen in China for one month, knocking on factory doors just for a behind-the-scenes glimpse of the toy production process.
Being one of his first times to China, the mammoth scale of the industry came as a major “culture shock” to Aw.
Mighty Jaxx founder and CEO Jackson Aw. Photo: Toh Ee Ming
Mighty Jaxx founder and CEO Jackson Aw. Photo: Toh Ee Ming

“I had always thought that it was just one giant machine that spits out parts and that was it. But there were rows and rows of hundreds of people printing, hand painting, assembling and using different skills just to produce one toy,” the Singaporean says.

Describing the visit as his “greatest education”, Aw was inspired to launch Mighty Jaxx from his bedroom with start-up capital of S$20,000 loaned from a bank through his parents.

Fast forward to today and his online business has worked with major brands such as Warner Brothers, DC Comics, Cartoon Network, MTV and New Balance, and shipped millions of products to collectors in over 50 countries. It is best known for its XXRAY figures, developed in partnership with artist Jason Freeny, which feature dissected Justice League characters such as Batman, Superman and Wonder Woman.

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But in its early days, the China market had intimidated Aw as a “big anomaly” that was still largely closed off. Aw had found it difficult to navigate the cultural norms and familiarise himself with unfamiliar business models.

Still, sensing China’s potential, his firm embarked on wide-ranging creative collaborations to tailor its offerings to the Chinese market – from creating yin-and-yang themed toys, celestial chicken fairy deities and the “Hambuddha” (a Buddha holding a pearl-shaped hamburger while on a lotus throne).

It also partnered with Chinese artist Chen Wei (who goes by the alias Cacooca) to develop a new Panda Ink collection, which depicts a panda in the midst of an everyday activity or hobby, such as hiking, playing video games or cuddling with cats.

Mighty Jaxx’s ‘Flow by 18 Uppercut’ has a yin and yang theme with white and black halves. Photo: Mighty Jaxx
Mighty Jaxx’s ‘Flow by 18 Uppercut’ has a yin and yang theme with white and black halves. Photo: Mighty Jaxx

It has also collaborated with other big-name artists and celebrities trending among Chinese consumers – such as Los Angeles-based dance crew Kinjaz, who found fame in China appearing on dance shows, and ABS, a leading graffiti crew based in Beijing’s 798 Art District – and has an upcoming collaboration with Taiwanese singer Show Luo.

But it is the comic and toy conventions that provide its biggest fans, typically men in their 20s to 40s who flock in from Beijing, Shanghai and Guangzhou.

Aw says these collectors have a huge appetite to splurge on high-end collectibles, which can range in cost from anywhere between US$10 to US$2,000.

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To these collectors, price is of little concern as they are looking for “tangible products to buy and show off their personality” and build their street cred among their friends, though they still prefer to stay under-the-radar about their collection to the general public, Aw says.

Today, Mighty Jaxx’s products are manufactured in nearly 20 different factories in Shenzhen and Guangzhou. It set up its first overseas office in Shanghai last year and is planning to open its second one in Suzhou by the end of 2019, according to Aw.

Besides growing Chinese affluence, Aw credits his company’s success to a greater exposure to Western influences and China’s own unique brand of pop culture taking off domestically.

He points to one of China’s biggest blockbusters Monster Hunt, a fantasy martial arts film of how monsters live among humans.

Mighty Jaxx’s celestial chicken fairy deity is aimed at the Hong Kong and mainland China market. Photo: Mighty Jaxx
Mighty Jaxx’s celestial chicken fairy deity is aimed at the Hong Kong and mainland China market. Photo: Mighty Jaxx

“Outside China, you wouldn’t know what the hell it’s about. But the Chinese are creating their own unique narrative and developing their own intellectual property … That’s when we know the demand for original creation in different forms is truly there,” Aw says.

Likewise, consumers live in an age of a “mishmash of pop cultures and crossovers” and “subcultures becoming mainstream”, he says.

Citing how the business has teamed up with Team Hero, a China e-sports team comprising professional computer gamers, to roll out new figurines, Aw says: “It doesn’t mean that tattoo artists, skateboarders don’t buy toys … What seems to be separate demographics are converging to become a multibillion-dollar market.”

Aw says the company is planning to expand from its current business model based on direct selling to collectors, to e-commerce distribution channels like Taobao and Tmall by the end of 2019.

He hopes eventually to set up the firm’s first retail store in Shanghai, as he believes the future lies in experiential retail.

“China has been cultivating that openness in recent decades, and we’re still very curious and excited for new things to happen [in this market],” Aw says. 

Source: SCMP

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