Archive for ‘Influenza’

29/03/2020

Italian professor repeats warning coronavirus may have spread outside China last year

  • Giuseppe Remuzzi’s comments were seized on by Chinese state media amid the acrimonious row with the US, but he says the key question is how far Covid-19 had spread before it was identified
  • Academic says ‘strange pneumonias’ in Italy last November suggest it may have reached Europe before anyone knew what the disease was
Giuseppe Remuzzi told NPR there had been ‘strange pneumonias’ in Italy in November and December. Photo: Handout
Giuseppe Remuzzi told NPR there had been ‘strange pneumonias’ in Italy in November and December. Photo: Handout
The coronavirus that causes Covid-19 may have spread beyond China before the health authorities had even discovered the disease, according to the Italian professor who recently said there had been “very strange pneumonias” in Europe as early as November last year.
The comments by Giuseppe Remuzzi, director of the Mario Negri Institute for Pharmacological Research in Milan, during an interview with US National Public Radio last week were quickly seized upon in the increasingly acrimonious blame game between Washington and Beijing
.
Remuzzi’s comments attracted much attention in China, where the authorities have been working hard to steer the international narrative about the pandemic, and stop people describing it as the “China virus” or “Wuhan virus” after the city where the disease was first identified.
In an interview with the Chinese science and technology news outlet DeepTech, which was published on Tuesday, Remuzzi said the key point in his NPR interview was not where the virus came from, but how far it had spread before it was discovered.
Coronavirus: Italy has a brief glimpse of hope as new cases drop to a five-day low
24 Mar 2020

He said a major question was how long the disease, which has so far infected more than 378,000 and killed over 16,500 people worldwide, had been spreading in China before health authorities realised its severity.

Taking into account the long incubation period, Remuzzi said he would not be surprised if some asymptomatic carriers had travelled around China or even abroad before December.

The professor also said that while it was possible it originated outside Wuhan, there had so far been no proof to support the theory.

As the outbreak gathered pace in the US, where it has now killed more than 500 people, Washington has escalated its rhetoric. President Donald Trump had repeatedly referred to it publicly as the “Chinese virus” until he changed tone on Monday and declined to use the phrase.

China, meanwhile, has described the rhetoric adopted by “certain US politicians and senior officials” as an attempt to defame and stigmatise China over the pandemic.

A number of Chinese state media outlets, including party mouthpiece People’s Daily and its tabloid affiliate Global Times, seized on Remuzzi’s comments about “strange pneumonias” to counter the “Chinese virus rhetoric”.

Coronavirus: why are so many more people dying in Italy than Germany?

23 Mar 2020

In the NPR interview, Remuzzi tried to explain why Italy had been caught off guard when the outbreak started gathering pace in February.

He discussed the difficulty of combating a disease that people did not know existed, and said the unusual cases in November and December could mean that virus was already circulating in Lombardy, the country’s worst-hit region, before people were aware of what was unfolding in Wuhan.

Remuzzi also shared details of the early suspected cases in Lombardy with DeepTech and Chinese state-run international network CGTN.

Remuzzi said he had learned about the cases from a few general practitioners and he has not yet been able to verify the information.

But he said there are some other suspicious cases he “knows for sure”, including two pneumonia cases in Scanzorosciate in northern Italy in December, where the patients developed high fever, a cough and had difficulty in breathing.

He said there had also been 10 patients who developed bilateral interstitial pneumonia in two other nearby towns, Fara Gera D’Adda and Crema, who had similar symptoms.

Coronavirus: confusion as Chinese face masks bound for Italy end up in Czech Republic

23 Mar 2020

Remuzzi said local doctors considered these cases to be “unusual” but ruled out the possibility of seasonal influenza, as all these patients had been vaccinated.

“The reason we don’t know if it was Covid-19 is because at that time this could not be tested; the patients didn’t have X-rays,” he told CGTN.

They recovered within 15 days, with some receiving two or three courses of antibiotics.

Remuzzi added there had also been a patient diagnosed with bilateral interstitial pneumonia in Alzano Lombardo Hospital in Lombardy around the time.

Source: SCMP

20/03/2020

Coronavirus: Why is India testing so little?

A visitor wears a mask as a precautionary measure against Corona virus at the Volkswagen showcasing hall during the India Auto Expo 2020 in Greater Noida, India, 05 February 2020.Image copyright EPA
Image caption The world’s second-most populous country has reported about 182 infections

“We have a simple message to all countries – test, test, test,” World Health Organisation (WHO) head Tedros Adhanom Ghebreyesus told reporters in Geneva earlier this week.

He was alluding to the coronavirus outbreak, which has killed more than 10,000 people and infected nearly 250,000 in at least 159 countries.

“All countries should be able to test all suspected cases, they cannot fight this pandemic blindfolded,” he said.

With 182 reported infections and four deaths so far, is India taking this advice seriously? Is the world’s second-most populous country testing enough?

The jury is out on this one. India had tested some 14,175 people in 72 state-run labs as of Thursday evening – one of the lowest testing rates in the world. The reason: the country has limited testing. So, only people who have been in touch with an infected person or those who have travelled to high-risk countries, or health workers managing patients with severe respiratory disease and developing Covid-19 symptoms are eligible for testing.

Why is a densely populated country with more than a billion people testing so little? The official assumption is the disease has still not spread in the community. As early “evidence” health authorities say 826 samples collected from patients suffering from acute respiratory disease from 50 government hospitals across India between 1 and 15 March tested negative for coronavirus. Also, hospitals have not yet reported a spike in admissions of respiratory distress cases.

“It is reassuring that at the moment there is no evidence of community outbreak,” says Balram Bhargava, director of the Indian Council of Medical Research (ICMR). He believes Mr Ghebreyesus’s advice is “premature” for India, and it would only “create more fear, more paranoia and more hype”.

Media caption Dr Ramanan Laxminarayan: “India’s going to be the next hot spot for this epidemic”

But experts are not so sure.

Many of them believe India is also testing below scale because it fears that its under-resourced and uneven public health system could be swamped by patients. India could be buying time to stock up on testing kits and add isolation and hospital beds. “I know mass testing is not a solution, but our testing appears to be too limited. We need to quickly expand to restrict community transmission,” K Sujatha Rao, former federal health secretary and author of But Do We Care: India’s Health System, told me.

On the other hand, say virologists, random, on-demand testing will create panic and completely strain the feeble public health infrastructure. Increased and targeted “sentinel screening” of patients suffering from influenza and diagnoses in hospitals across the country can provide a better idea of whether there is community transmission, they say. “We need focused testing. We cannot do a China or Korea because we simply don’t have the capacity,” a senior virologist told me.

In many ways, it is all about India trying to battle a pandemic with limited resources. Experts talk about the country’s success in defeating polio, combating small pox, successfully controlling the spread of HIV/Aids, and more recently H1N1 with rigorous surveillance, sharp identification of vulnerable people, targeted intervention, and an early engagement with the private sector to prevent disease spread.

Yet, coronavirus is one of the deadliest transmissible viruses in recent history. Every day lost in effective response means the looming danger of a surge in infections. India spends a paltry 1.28% of its GDP on health care, and that may begin to bite if there’s a full-blown outbreak. Partial lockdowns in many cities – shutting schools, colleges, businesses and suspending some rail transport – proves that the government fears that community transmission of the virus might have begun.

A security guard (L) takes the temperature of a patron as a preventive measure against the COVID-19 novel coronavirus before he enters a Starbucks coffee shop in New Delhi on March 17, 2020Image copyright GETTY IMAGES
Image caption The official assumption is the disease has still not spread in the community

Bracing for the inevitable, India is scaling up testing. Officials say existing labs are able to provide results in six hours and each lab has the capacity to test 90 samples a day which can be doubled. Fifty more state labs are expected to begin testing samples by the end of the week, bringing the total number of testing facilities to 122. Authorities claim that together, the labs will be able to test 8,000 samples a day – a significant scaling up. In addition, the government is planning to allow around 50 private labs to start testing, but they will take up to 10 days to procure kits. (Testing at state-run labs is free, and it is unclear whether the private labs will charge.)

Two rapid testing labs, capable of doing 400 tests a day, are expected to be operational by the end of the week. India has also placed orders for a million test kits, and will be possibly asking the WHO for a million more.

“On testing, the government response has been proportionate, taking into account scope, need and capacity,” Henk Bekedam, WHO Representative to India told me. “We recognise that laboratory networks are expanding the scope and testing and they now include patients with severe acute respiratory infection and influenza-like illness detected through the surveillance system. It would also be important to look at ‘atypical pneumonia’ cases. If they are without any distinctive cause, then they need to be considered for testing.”

A doctor seen wearing protective suit to protect himself form coronavirus epidemic in the country, at RML Hospital on March 16, 2020 in New Delhi, IndiaImage copyright GETTY IMAGES
Image caption India could be buying time to stock up on testing kits and add isolation and hospital beds

The weeks and months ahead will show whether these steps have been enough. “We cannot say India has escaped community transmission,” Mr Bhargava says candidly. And if and when there is an explosion of infections and more sick people require hospitalisation, India will face formidable challenges.

India has eight doctors per 10,000 people compared to 41 in Italy and 71 in Korea. It has one state-run hospital for more than 55,000 people. (Private hospitals are out of reach for most people). The country has a poor culture of testing, and most people with flu symptoms do not go to doctors and instead try home remedies or go to pharmacies. There’s a scarcity of isolation beds, trained nursing staff and medics, and ventilators and intensive care beds.

India’s influenza cases peak during the monsoon season, and there is no reason why the coronavirus will not make a second coming, virologists say. “Given the way it is progressing in India, it seems it is about two weeks behind Spain and three weeks behind Italy. But that’s the number of known cases. And without sufficient testing and shutting down large gatherings, the numbers could be a lot worse,” Shruti Rajagopalan, economist and a Senior Research Fellow at the Mercatus Center at George Mason University, told me.

India’s traditional neglect of public healthcare will begin to bite if the disease spreads to its teeming small towns and villages. “This is a very unique and real public health challenge,” says Ms Rao. And it’s early days yet.

Source: The BBC

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