Archive for ‘induced’

29/04/2020

Coronavirus: Oxford vaccine effective in monkeys, heading for mass production in India

  • Six animals inoculated with vaccine candidate then exposed to virus did not catch Covid-19 after 28 days
  • Up to 60 million doses could be produced by Serum Institute of India this year
Microbiologist Elisa Granato gets an injection on Thursday as part of the first human trials in Britain for a potential coronavirus vaccine. Photo: University of Oxford via AP
Microbiologist Elisa Granato gets an injection on Thursday as part of the first human trials in Britain for a potential coronavirus vaccine. Photo: University of Oxford via AP

A leading candidate for a Covid-19 vaccine has shown promising results in animal trials, and is expected to see mass production in India within months.

The Serum Institute of India, the world’s largest maker of vaccines by volume, said on Tuesday that it plans this year to produce up to 60 million doses of a potential vaccine developed by the University of Oxford, which is under clinical trial in Britain.

While the vaccine candidate, called “ChAdOx1 nCoV-19”, is yet to be proven to work against Covid-19, Serum decided to start manufacturing it as it had shown success in animal trials and had progressed to tests on humans, Serum Chief Executive Adar Poonawalla said.

Six rhesus macaque monkeys were inoculated with the vaccine candidate at the National Institutes of Health’s Rocky Mountain Laboratory in Montana last month, according to The New York Times.

Covid-19 vaccine trial starts in Oxford, but remdesivir treatment reportedly flops in China tests
The subjects were exposed afterwards to large quantities of the novel coronavirus, but all six remained healthy after more than 28 days, the newspaper reported, citing researcher Vincent Munster, who conducted the test.

More than 3 million people have been reported to be infected globally and over 210,000 have died from Covid-19, the respiratory disease caused by the coronavirus.

“They are a bunch of very qualified, great scientists [at Oxford] … That’s why we said we will go with this and that’s why we are confident,” Poonawalla told Reuters in a phone interview.

“Being a private limited company, not accountable to public investors or bankers, I can take a little risk and sideline some of the other commercial products and projects that I had planned in my existing facility,” Poonawalla said.

Bill Gates hopes his virus vaccine ‘manufacturing within a year’

27 Apr 2020

As many as 100 potential Covid-19 candidate vaccines are now under development by biotech and research teams around the world, and at least five of these are in preliminary testing in people in what are known as phase one clinical trials.

Poonawalla said he hoped trials of the Oxford vaccine, due to finish in about September, would be successful. Oxford scientists said last week the main focus of initial tests was to ascertain not only whether the vaccine worked but that it induced good immune responses and no unacceptable side effects.

Serum, owned by the Indian billionaire Cyrus Poonawalla, plans to make the vaccine at its two manufacturing plants in the western city of Pune, aiming to produce up to 400 million doses next year if all goes well, Poonawalla said.

“A majority of the vaccine, at least initially, would have to go to our countrymen before it goes abroad,” he said, adding that Serum would leave it to the Indian government to decide which countries would get how much of the vaccine and when.

Rhesus macaque monkeys are often used in animal testing because of their similarity to humans. Photo: AFP
Rhesus macaque monkeys are often used in animal testing because of their similarity to humans. Photo: AFP
Serum envisages a price of 1,000 rupees (US$14.70) per vaccine, but governments would give it to people without charge, he said.

He said Prime Minister Narendra Modi’s office was “very closely” involved in the vaccine production and the company is hoping the government will help foot the cost of making it.

Over roughly the next five months, Serum will spend some 300 million to 400 million rupees (US$4.4 million to US$5.9 million) on making around 3-5 million doses per month, he said. “[The government] are very happy to share some risk and fund something with us, but we haven’t really pencilled anything down yet,” Poonawalla said.

Coronavirus: clinical trial begins on third vaccine candidate in China

22 Apr 2020

Serum has also partnered with the US biotech firm Codagenix and Austria’s Themis on two other Covid-19 vaccine candidates and plans to announce a fourth alliance in a couple of weeks, he said.

Serum’s board last week also agreed to invest roughly 6 billion rupees (US$8.8 billion) on making a new manufacturing unit to solely produce coronavirus vaccines, Poonawalla said.

Source: SCMP

05/09/2019

Chinese teenager who lost her hair from stress of chasing grades sparks debate about pressure on young people

  • Doctor who helped 13-year-old girl recover says demands on her to do well at school induced condition
  • Weibo poll reveals that 68 per cent of participants had hair loss in school
Studies and polls suggest stress leading to hair loss is a big health concern in China. Photo: Alamy
Studies and polls suggest stress leading to hair loss is a big health concern in China. Photo: Alamy

When the 13-year-old girl walked into the hospital in southern China around eight months ago, she was almost completely bald, and her eyebrows and eyelashes had gone.

“The patient came with a hat on and did not look very confident,” Shi Ge, a dermatologist at the Sixth Affiliated Hospital of Sun Yat-sen University in Guangzhou, told the Pear Video news portal.

The girl had done well in primary school but her grades dropped in middle school, Shi said.

Under parental pressure to do well, the girl pushed herself harder, but the stress resulted in severe hair loss.

With time and medical treatment, the teen’s hair grew back but her story left a lasting impression, raising awareness of the increasing number of young people in China seeking treatment for stress-induced hair loss, according to Chinese media reports.

Jia Lijun, a doctor at Shenzhen Traditional Chinese Medicine Hospital, told state-run Xinhua News Agency in May that aside from genetics, factors such as stress in work, study and life would result in endocrine imbalances which affected the cycle of hair growth.

And in January, a survey of 1,900 people by China Youth Daily found that 64.1 per cent of people aged between 18 and 35 said they had hair loss resulting from long and irregular working hours, insomnia, and mental stress.

Hits and myths: stress and hair loss
Shi said that an increasing number of young people had come to her for treatment of hair loss in recent years, and those working in information technology and white-collar jobs were the two biggest groups.

“They usually could not sleep well at night due to high pressure or had an irregular diet because of frequent business trips,” Shi said.

A Weibo poll on Wednesday revealed that 68 per cent out of 47,000 respondents said they had had serious hair loss when they were in school. About 22 per cent said they noticed after starting their careers, while only 5 per cent said it happened after they entered middle age.

More than half of the Chinese students who took part in a China Youth Daily survey said they had hair loss. Photo Shutterstock
More than half of the Chinese students who took part in a China Youth Daily survey said they had hair loss. Photo Shutterstock

Research published in 2017 by AliHealth, the health and medical unit of the Alibaba Group, found that 36.1 per cent of Chinese people born in the 1990s had hair loss, compared to the 38.5 per cent born in the 1980s. Alibaba is the parent company of the South China Morning Post.

The teenager’s experience sparked a heated discussion on Weibo, with users recounting similar cases and some voicing their panic.

“My niece’s hair was gone while she was in high school and has not recovered, even after she graduated from university. This makes her feel more and more inferior,” one user said.

Hong Kong’s schoolchildren are stressed out – and their parents are making matters worse

Another said: “I lost a small portion of my hair during the high school entrance exam, but that is already scary enough for a girl in her adolescence.”

“I had to quit my job and seek treatment,” said a third, who adding that he also suffered from very serious hair loss a few months ago because of high pressure.

Source: SCMP

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