Archive for ‘MRC Centre for Global Infectious Disease Analysis’

23/01/2020

Coronavirus: Wuhan shuts public transport over outbreak

Wuhan, a Chinese city of eleven million people, has temporarily shut down its public transport as it tries to halt the outbreak of a new strain of virus.

Those living in the city have been advised not to leave, in a week when millions of Chinese are travelling for the upcoming Lunar New Year holiday.

The respiratory illness has spread to other parts of China, with some cases in other countries including the US.

There are more than 500 confirmed cases and 17 people have died.

Known for now as 2019-nCoV, the virus is understood to be a new strain of coronavirus not previously identified in humans. The Sars (severe acute respiratory syndrome) virus that killed nearly 800 people globally in the early 2000s was also a coronavirus, as is the common cold.

All the fatalities so far have been in Hubei, the province around Wuhan.

Meanwhile, after a day of discussions in Geneva, the World Health Organization’s (WHO) emergency committee has announced it will not yet declare a “global emergency” over the new virus.

Director general Dr Tedros Ghebreyesus said more information was needed about the spread of the infection. The committee of health experts will meet again on Thursday.

A global emergency is the highest level of alarm the WHO can sound and has previously been used in response to swine flu, Zika virus and Ebola.

What measures have been announced?

From Thursday, all flights and passenger train services out of Wuhan have been stopped.

Bus, subway and ferry services all shut down from 10:00 local time (02:00 GMT).

A special command centre in Wuhan set up to contain the virus said the move was meant to “resolutely contain the momentum of the epidemic spreading”.

Map of Wuhan transportThose living in Wuhan had already been told to avoid crowds and minimise public gatherings.

State news agency Xinhua said tourist attractions and hotels in the city had been told to suspend large-scale activities while libraries, museums and theatres were cancelling exhibitions and performances.

A Lunar New Year prayer-giving ceremony at the city’s Guiyuan Temple, which attracted 700,000 people last year, has also been cancelled.

The hashtag “Wuhan is sealed off” was trending on Chinese social media website Weibo.

One user said worries about food and disinfectant made it feel like “the end of the world”, while another said they were on the “verge of tears” when Chinese officials announced the shut-down.

The WHO’s Dr Ghebreyesus described the latest measures as “very strong” and said they would “not only control the outbreak, they will minimise spread internationally”.

Chinese officials said the country was now at the “most critical stage” of prevention and control.

“Basically, do not go to Wuhan. And those in Wuhan please do not leave the city,” said National Health Commission vice-minister Li Bin in one of the first public briefings since the beginning of the outbreak.

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Like shutting down London before Christmas

By James Gallagher, BBC health and science correspondent

Wuhan is starting to look like a city in quarantine.

Officials had already warned residents not to leave the city and visitors not to come.

Now the reported public transport ban – which includes flights – slams many of the routes in and out of the city shut.

A man wears a mask on the subway on January 22, 2020 in Wuhan, Hubei province, ChinaImage copyright GETTY IMAGES
Image caption Subways in Wuhan will be temporarily shut

It is a significant attempt to stop the spread of this new virus, which we now know can spread from person to person.

Limiting transport will cut the chance of the virus reaching other cities in China and other countries around the world.

This all comes just as millions of people are travelling across China for the week-long holiday that is Lunar New Year.

If you’re struggling for context – imagine shutting down London in the week before Christmas.

The big question left is the roads – and whether any of Wuhan’s 11 million inhabitants will be able to simply drive away.

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What’s the picture globally?

Officials in Hong Kong reported the territory’s first two cases on Wednesday and one case was reported in the nearby city of Macau.

The patient in Macau is said to be a businesswoman who arrived from Wuhan over the weekend.

The first US case was confirmed on Tuesday. President Donald Trump said the situation was “totally under control” and that he trusted the information being provided by Chinese authorities.

Map: Confirmed cases in China and around the world
There have been three cases in Thailand, one in Korea, one in Japan and one in Taiwan.

Although only about 500 cases have been confirmed, calculations by scientists at the MRC Centre for Global Infectious Disease Analysis at Imperial College London suggest there are 4,000 people sick with the virus in Wuhan.

What do we know about the virus?

The virus originated in a seafood market in Wuhan that “conducted illegal transactions of wild animals”, authorities said. The market has since been shut down.

There is also evidence of human to human transmission with the new virus spreading to family members and healthcare workers.

But understanding how easily and how often the virus spread between people is one of the major outstanding questions in this outbreak.

The virus infects the lungs and symptoms start with a fever and cough. It can progress to shortness of breath and breathing difficulties.

Source: The BBC

20/01/2020

China confirms spread of new virus as cases surge

BEIJING (Reuters) – An outbreak of a new coronavirus in China has spread to more cities, Chinese authorities said on Monday, as the number of patients tripled and a third person died, stoking concerns about containment of the illness.

The Daxing health commission in the capital Beijing said it had confirmed two cases of coronavirus, while the southern Guangdong province’s health commission confirmed one case in Shenzhen. They mark the first cases in China beyond the central city of Wuhan where the virus first emerged.

The Wuhan Municipal Health Commission said 136 new cases of pneumonia caused by the coronavirus strain had been found in the city over the weekend, adding to 62 already known cases. A third death occurred on Saturday, the authority said in a statement.

This brings the total number of known cases worldwide to more than 200, underscoring the challenge for health authorities seeking to contain the outbreak. South Korea on Monday reported its first confirmed case of the coronavirus, a 35-year-old female Chinese national who had travelled from Wuhan, the fourth patient to be reported outside China.

Hundreds of millions of Chinese tourists will be traveling domestically and abroad during the Lunar New Year holiday period that starts later this week.

A report by London Imperial College’s MRC Centre for Global Infectious Disease Analysis estimated that by Jan. 12 there were 1,723 cases in Wuhan City with onset of related symptoms. Chinese health authorities have not commented directly on the report.

CONTAINMENT EFFORTS

Authorities around the globe, including in the United States and many Asian countries, have stepped up screening of travellers from Wuhan. Last week, two cases were reported in Thailand and one in Japan. All three involved people from Wuhan or who recently visited the city.

The virus belongs to the same family of coronaviruses as Severe Acute Respiratory Syndrome (SARS), which killed nearly 800 people globally during a 2002/03 outbreak that also started in China.

Its symptoms include fever and difficulty in breathing, which are similar to many other respiratory diseases and pose complications for screening efforts.

China’s National Health Commission said on Sunday it will step up prevention efforts, but acknowledged it still doesn’t know the source of the virus.

Shares in pharmaceutical firms and mask makers in China surged Monday because of the outbreak.

The outbreak was one of the top trending topics on Chinese social media platform Weibo, where many users expressed concerns about their safety.

“Who knows how many people who have been to Wuhan may be unaware that they have already been infected?,” one user said.

China’s Global Times, published by the ruling Communist Party’s official People’s Daily newspaper, said in an editorial the government needs to disclose all information and not repeat the mistakes made with SARS. Chinese officials covered up the SARS outbreak for weeks before a growing death toll and rumours forced it to reveal the epidemic.

“Concealment would be a serious blow to the government’s credibility and might trigger greater social panic,” the editorial said.

Source: Reuters

18/01/2020

New Chinese virus ‘will have infected hundreds’

VirusesImage copyright GETTY IMAGES
Image caption There were six coronaviruses known to infect people before the latest discovery

The number of people already infected by the mystery virus emerging in China is far greater than official figures suggest, scientists have told the BBC.

There have been more than 60 confirmed cases of the new coronavirus, but UK experts estimate a figure nearer 1,700.

Two people are known to have died from the respiratory illness, which appeared in Wuhan city in December.

“I am substantially more concerned than I was a week ago,” disease outbreak scientist Prof Neil Ferguson, said.

The work was conducted by the MRC Centre for Global Infectious Disease Analysis at Imperial College London, which advises bodies including the UK government and the World Health Organization (WHO).

Singapore and Hong Kong have been screening air passengers from Wuhan, and US authorities announced similar measures starting on Friday at three major airports in San Francisco, Los Angeles and New York.

How were the numbers calculated?

The crucial clue to the scale of the problem lies in the cases being detected in other countries.

While the outbreak is centred on the central Chinese city of Wuhan, there have been two cases in Thailand and one in Japan.

“That caused me to worry,” said Prof Ferguson.

He added: “For Wuhan to have exported three cases to other countries would imply there would have to be many more cases than have been reported.”

It is impossible to get the precise number, but outbreak modelling, which is based on the virus, the local population and flight data, can give an idea.

Wuhan International Airport serves a population of 19 million people, but only 3,400 a day travel internationally.

The detailed calculations, which have been posted online ahead of publication in a scientific journal, came up with a figure of 1,700 cases.

What does it all mean?

Prof Ferguson said it was “too early to be alarmist” but he was “substantially more concerned” than a week ago.

Chinese officials say there have been no cases of the virus spreading from one person to another.

Instead they say the virus has crossed the species barrier and come from infected animals at a seafood and wildlife market in Wuhan.

Prof Ferguson argues: “People should be considering the possibility of substantial human-to-human transmission more seriously than they have so far.

“It would be unlikely in my mind, given what we know about coronaviruses, to have animal exposure, be the principal cause of such a number of human infections.”

Understanding how a novel virus is spreading is a crucial part of assessing its threat.

The WHO’s China office said the analysis was helpful and would help officials plan the response to the outbreak.

“Much remains to be understood about the new coronavirus,” it said. “Not enough is known to draw definitive conclusions about how it is transmitted, the clinical features of the disease, the extent to which it has spread, or its source, which remains unknown.”

WuhanImage copyright GETTY IMAGES
Image caption The outbreak occurred in the city of Wuhan, south of Beijing

What is this virus?

Viral samples have been taken from patients and analysed in the laboratory.

And officials in China and the World Health Organization have concluded the infection is a coronavirus.

Coronaviruses are a broad family of viruses, but only six (the new one would make it seven) are known to infect people.

At the mild end they cause the common cold, but severe acute respiratory syndrome (Sars) is a coronavirus that killed 774 of the 8,098 people infected in an outbreak that started in China in 2002.

Analysis of the genetic code of the new virus shows it is more closely related to Sars than any other human coronavirus.

The virus has caused pneumonia in some patients and been fatal in two of them.

What do other experts say?

Dr Jeremy Farrar, director of the Wellcome medical research charity, said: “There is more to come from this epidemic.

“Uncertainty and gaps remain, but it’s clear that there is some level of person-to-person transmission.

Media caption Coronavirus feared to have infected more than initially thought, according to scientists

“We are starting to hear of more cases in China and other countries and it is likely, as this modelling shows, that there will be many more cases in a number of countries.”

Prof Jonathan Ball, from the University of Nottingham, said: “What’s really important is until there has been widespread laboratory testing it is very difficult to put a real number on the cases out there.

“But this is a figure we should take seriously until we know otherwise, 41 animal-to-human ‘spillovers’ is stretching it a bit and there probably is more underlying infection than has been detected so far.”

Source: The BBC

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