Archive for ‘Severe Acute Respiratory Syndrome (SARS)’

02/05/2020

How a llama could hold the key to beating the coronavirus

  • An antibody engineered from the animal’s immune system was found to neutralise the virus that causes Covid-19
  • American and Belgian researchers hope the discovery may help protect humans from the deadly illness
Winter the lama (front) lives on a farm operated by Ghent University's Vlaams Institute for Biotechnology. Photo: Tim Coppens
Winter the llama (front) lives on a farm operated by Ghent University’s Vlaams Institute for Biotechnology. Photo: Tim Coppens

A Belgian llama could hold the key to producing an antibody that neutralises the coronavirus that causes Covid-19.

More studies and clinical trials are needed to see if it can be used in humans to treat Covid-19, but the team of American and Belgian scientists who engineered the antibody said they were encouraged by their preliminary findings, which will be published in the journal Cell next week.

Jason McLellan, from the University of Texas at Austin and co-author of the study, described it as one of the “first antibodies known to neutralise Sars-CoV-2”, the official name for the virus.

“With antibody therapies, you’re directly giving somebody the protective antibodies and so, immediately after treatment, they should be protected,” he wrote in a press release.

“The antibodies could also be used to treat somebody who is already sick to lessen the severity of the disease.”
Winter the llama produced antibodies that proved effective against the Sars-CoV-2 virus. Photo: Tim Coppens
Winter the llama produced antibodies that proved effective against the Sars-CoV-2 virus. Photo: Tim Coppens
The scientists have been working on coronaviruses – including severe acute respiratory syndrome (Sars) and Middle East respiratory syndrome (Mers) – for years.

In 2016 they injected the llama, named Winter, with Sars and Mers in the hope of developing a treatment for the diseases.

“I thought this would be a small side project,” said Dorien De Vlieger from Ghent University in Belgium, who helped to isolate antibodies against coronaviruses from the llamas.

China’s race for a Covid-19 vaccine hits a hurdle – no outbreak at home

1 May 2020

“Now the scientific impact of this project became bigger than I could ever expect. It’s amazing how unpredictable viruses can be.”

A llama’s immune system produces two types of antibodies when it detects pathogens, one similar to human antibodies and one that is about a quarter of the size.

The antibodies produced by Winter were found to be effective in targeting the Sars virus’s spike protein, which allows it to bind to human cells.

Chinese firm ready to make 100 million Coronavirus vaccine doses if trials are successful
This year they decided to test the antibodies Winter had produced during the Sars experiment to see if it could prove effective against Covid-19.

Although it did bind itself to the Sars-CoV-2 virus it did so “weakly”, so the team then linked two copies of the antibody together to make it bind more effectively.

Oxford vaccine effective in monkeys, heading for mass production in India

30 Apr 2020

“That was exciting to me because I’d been working on this for years. But there wasn’t a big need for a coronavirus treatment then. This was just basic research,” said Daniel Wrapp from the University of Texas, a co-author of the study.

The smaller type of antibodies produced by llamas, called single-domain antibodies or nanobodies, can be used in an inhaler, according to Wrapp.

“That makes them potentially really interesting as a drug for a respiratory pathogen because you’re delivering it right to the site of infection,” said Wrapp.

Researchers created an antibody dubbed VHH-72Fc (blue) that binds tightly to the Sars-CoV-2 spike protein (pink, green and orange), blocking the virus from infecting cells. Photo: University of Texas at Austin
Researchers created an antibody dubbed VHH-72Fc (blue) that binds tightly to the Sars-CoV-2 spike protein (pink, green and orange), blocking the virus from infecting cells. Photo: University of Texas at Austin
The researchers are preparing for more trials with hamsters or primates to further test the antibody, before taking it to human trials.
The main subject of the study, Winter the llama, is now four years old and lives on a farm operated by Ghent University’s Vlaams Institute for Biotechnologym which said it has around 130 other llamas and alpacas at the facility.
Source: SCMP
17/03/2020

South Korea’s coronavirus response is the opposite of China and Italy – and it’s working

  • Seoul’s handling of the outbreak emphasises transparency and relies heavily on public cooperation in place of hardline measures such as lockdowns
  • While uncertainties remain, it is increasingly viewed by public health experts as a model to emulate for authorities desperate to keep Covid-19 in check
A woman wearing a face mask walks along the Han river at a park in Seoul, South Korea. Photo: AP
A woman wearing a face mask walks along the Han river at a park in Seoul, South Korea. Photo: AP
For weeks, the graph charting new cases of Covid-19 in South Korea rose in a steep line – a literal illustration of the rapid, seemingly unstoppable spread of the coronavirus. Then the line began to curve.
After announcing 600 new cases for March 3, the authorities reported 131 new infections a week later. On Friday, officials reported just 110, the lowest daily toll since February 21. The same day, the number of recovered patients, 177, exceeded new infections for the first time.President Moon Jae-in, while cautioning against premature optimism, has expressed hope that South Korea could soon enter a “phase of stability” if the trend holds firm.
With about 8,000 confirmed cases and more than 65 deaths, it was until recently the country with the most confirmed cases outside China – but South Korea has since emerged as a source of inspiration and hope for authorities around the world as they scramble to fight the pandemic.
South Korea’s infection rate falls without citywide lockdowns like China, Italy
11 Mar 2020

As countries ranging from the United States to Italy and Iran struggle to manage the virus, Seoul’s handling of the outbreak – involving a highly coordinated government response that has emphasised transparency and relied heavily on public cooperation in place of hardline measures such as lockdowns – is increasingly viewed by public health experts as a model to emulate for authorities desperate to keep the virus under control.

Whereas China, where the virus originated, and more recently Italy have placed millions of their citizens on lockdown, South Korea has not restricted people’s movements – not even in Daegu, the southeastern city at the centre of the country’s outbreak.

Instead, authorities have focused mandatory quarantine on infected patients and those with whom they have come into close contact, while advising the public to stay indoors, avoid public events, wear masks and practise good hygiene.

South Korean President Moon Jae-in visits the Korea Centres for Disease Control and Prevention on March 11. Photo: EPA
South Korean President Moon Jae-in visits the Korea Centres for Disease Control and Prevention on March 11. Photo: EPA
And while numerous countries have imposed sweeping travel bans – including the US, which has introduced dramatic restrictions on travel from Europe – Seoul has instead introduced “special immigration procedures” for heavily affected countries such as China, requiring travellers to undergo temperature checks, provide verified contact information and fill out health questionnaires.

[South Korea’s] approach seems less dramatic and more usable by other countries, compared with that used in mainland China – Ian MacKay, virologist at the University of Queensland

“More than a week of downward-trending case counts shows that the approach in South Korea has turned around an epidemic,” said Ian Mackay, a virologist at the University of Queensland, Australia. “This approach seems less dramatic and more usable by other countries, compared with that used in mainland China. If these trends continue, they will have managed to stop the growth of their epidemic.”

‘A SPECTACULAR FEAT’

The linchpin of South Korea’s response has been a testing programme that has screened more people per capita for the virus than any other country by far. By carrying out up to 15,000 tests per day, health officials have been able to screen some 250,000 people – about one in every 200 South Koreans – since January.

To encourage participation, testing is free for anyone referred by a doctor or displaying symptoms after recent contact with a confirmed case or travel to China. For anyone simply concerned about the risk of infection, the cost is a relatively affordable 160,000 won (US$135). Testing is available at hundreds of clinics, as well as some 50 drive-through testing stations that took their inspiration from past counterterrorism drills and can screen suspected patients in minutes.

“This country has a universal health-coverage system for the whole population and the economic burden for testing is very low,” said Kim Dong-hyun, president of the Korean Society of Epidemiology. “Tests are conducted for free if you have proper symptoms.”

The massive volume of data collected has enabled the authorities to pinpoint clusters of infection to better target their quarantine and disinfection efforts, and send members of the public text-message alerts to inform them of the past movements of infected patients in their area – even down to the names of shops and restaurants they visited.

This country has a universal health coverage system for the whole population and the economic burden for testing is very low – Kim Dong-hyun, president of the Korean Society of Epidemiology

“South Korea’s capability to test for early detection of viruses has developed greatly as it went through the 2009 new influenza outbreak and 2015 Mers [Middle East respiratory syndrome] outbreak,” said Kim Woo-joo, a professor of medicine at Korea University’s College of Medicine. “It ranks among the world’s top countries in this field.”

South Korea’s ‘drive-through’ coronavirus testing stations
Collecting this amount of data has also allowed the South Korean authorities to glean a clearer indication of the potential lethality of the virus, the fatality rate of which has diverged significantly from about 5 per cent in Italy to about 0.8 per cent in South Korea. Although factors including quality of health care, patient age and public awareness can affect the fatality rate of a virus, the scale of testing is among the most influential.

By comparison, in neighbouring Japan – which has confirmed more than 600 cases, not including the virus-stricken Diamond Princess cruise ship – the authorities had as of Friday tested over 10,000 people.

In the United States, where the authorities are unable to confirm the number of tests since they are being carried out by a patchwork of federal, state and private laboratories, the total was estimated to be fewer than 5,000 in a survey of available data by The Atlantic.

William Schaffner, a professor of preventive medicine and infectious diseases at Vanderbilt University School of Medicine in the US, said South Korea had pulled off a “spectacular” feat that was allowing health officials to track the virus and assess its intensity.

“We are unsure where our infection is and how intensely it is being transmitted in the US and we are only now starting to test,” he said.

Coronavirus is now classified as a pandemic

13 Mar 2020

South Korea is not unique in claiming some success in its fight against the virus. Singapore, Taiwan and Hong Kong, informed by past outbreaks such as severe acute respiratory syndrome (Sars) and Mers, have managed to keep confirmed cases low while eschewing the sort of draconian measures implemented in mainland China.

Early on, Hong Kong took some of the most comprehensive steps to implement “social distancing” – in which events are cancelled and venues closed to minimise contact between people – by shutting schools in late January, while the authorities produced a digital map of confirmed cases to allow people to avoid potentially infected areas.

In Taiwan, officials have pooled information from immigration and health insurance databases to track people’s travel histories and symptoms, and used phone tracking to ensure compliance with quarantine. Singapore has similarly tracked infected patients and traced their contacts, with stiff penalties for those who disobey quarantine or mislead the authorities about where they have travelled.

A worker disinfects a Seoul subway station as a precaution against the new coronavirus. Photo: AP
A worker disinfects a Seoul subway station as a precaution against the new coronavirus. Photo: AP
OPENNESS AND TRANSPARENCY
But where South Korea has stood apart is seemingly turning the tide against a major outbreak while maintaining openness and transparency. The largest cluster of cases in the country is linked to a secretive religious sect, Shincheonji, members of which have been accused of negligently spreading the virus as well as evading medical follow-ups and testing.

In addressing the Covid-19 outbreak, sound decision-making should not be about making a choice between maximised protection or minimal disruption – Yanzhong Huang, Council on Foreign Relations

“South Korea’s experience suggests that a country can contain the spread of the virus in a relatively short period of time without relying on draconian, at-all-costs containment measures,” said Yanzhong Huang, a senior fellow for global health at the Council on Foreign Relations in New York.

“For countries like the US, the Korean experience offers an acceptable, likely more viable, alternative to addressing the outbreak. In addressing the Covid-19 outbreak, sound decision-making should not be about making a choice between maximised protection and minimal disruption.”

China effectively barred 60 million people in Wuhan – ground zero of the outbreak – and the rest of the province of Hubei from leaving their homes, while restricting the movements of hundreds of millions of others across the country by shutting down public transport, banning private cars and setting up roadblocks.

‘I was stupidly overconfident’: a Korean coronavirus survivor’s tale

15 Mar 2020

The country claims to have effectively halted the spread of the virus after recording more than 80,000 cases and 3,100 deaths, and its daily updates have in recent weeks fallen from thousands of new cases to dozens. However, scepticism lingers over official figures after local and provincial officials in Hubei initially tried to hide the extent of the outbreak.

In a move widely seen to be aimed at touting the success of Beijing’s hardline measures, Chinese President Xi Jinping on Tuesday made his first visit to Wuhan, during which he called for businesses and factories to return to work as normal and for the country to refocus on economic growth.

“While China has been able to control Covid-19, I don’t think its draconian methods are worth copying in liberal democracies,” said Lawrence Gostin, director of the O’Neill Institute for National and Global Health Law at Georgetown University Law Centre in Washington. “Most democracies value human rights and freedoms … [not] the degree of social control we’ve seen in China. South Korea offers a better model.”

A nearly empty customer call centre in the Gocheok-dong neighbourhood of Seoul as workers isolate or work from home. Photo: EPA
A nearly empty customer call centre in the Gocheok-dong neighbourhood of Seoul as workers isolate or work from home. Photo: EPA
But in a striking indication that Beijing’s harsh tactics could inform even liberal democratic societies, Italy on Monday announced a nationwide quarantine after a massive spike in cases caught the authorities off guard. Shops, restaurants and bars have been closed, while public gatherings and most travel have been banned in the European country, which has confirmed more than 15,000 cases and 1,000 deaths as of Friday – making it the site of the biggest outbreak outside China.
In the Philippines, President Rodrigo Duterte on Thursday announced a lockdown of the entire Metro Manila region and its 12.8 million people.
David Hui Shu-cheong, an expert in respiratory medicine at the Chinese University of Hong Kong, said Italy had responded “very slowly” to the outbreak, in contrast to South Korea.
Southeast Asia at risk of missing coronavirus cases amid dengue outbreak: experts
11 Mar 2020

Even as Beijing touted its success at fighting the virus, with state media recently insisting the “world owes China a ‘thank you’”, South Korea – which democratised in the late 1980s following decades of military dictatorship – has made no secret of its desire to promote a more liberal alternative.

At a press conference with foreign media this week, vice-health minister Kim Gang-lip said that while drastic measures such as locking down affected areas had demonstrated “modest effectiveness”, they suffered from being “coercive and inflexible”.

“Korea, as a democratic country, values globalisation and a pluralistic society,” he said.

“Therefore we believe we must transcend the limitations of the conventional approach to fighting infectious disease.”

Kim stressed that public trust was crucial to the government’s strategy. “The more transparently and quickly accurate information is provided, the more the people will trust the government,” he said. “They will act rationally for the good of the community at large.”

South Korean ministers listen to Prime Minister Chung Sye-kyun (on screen) during a meeting to discuss measures to deal with the spread of the new coronavirus. Photo: EPA
South Korean ministers listen to Prime Minister Chung Sye-kyun (on screen) during a meeting to discuss measures to deal with the spread of the new coronavirus. Photo: EPA
UNKNOWN FACTORS
Although the authorities have shut down schools nationwide, South Koreans have largely embraced self-isolation and social distancing of their own accord.
In the past fortnight, more than 12,000 businesses have applied for subsidies to pay the wages of employees while they temporarily close their doors due to the outbreak, according to the country’s labour ministry. Many shops in Daegu, the site of more than three-quarters of the country’s cases, have shut their doors, while shopping malls and cinemas across the country have become largely deserted as people stay at home. Catholic churches and Buddhist temples nationwide have suspended mass and prayer services.
“To an outsider, South Korea has handled an enormous surge in cases very well and seemed to mitigate further spread through forms of … passive social isolation,” said Howard P. Forman, a professor of public health policy at Yale School of Management.
Indonesian firms doing business with China face tough times with coronavirus outbreak
12 Mar 2020

Some experts suggest South Korean society’s emphasis on discipline and community may have given it room to avoid implementing more draconian measures.

“This measure appears to have been very successful but is reliant on the local population working with the response,” said Jeremy Rossman, an honorary senior lecturer in virology at the University of Kent. “It is not clear how effective this approach would be in other cultures and it does require effective communication with the local population.”

How a secretive church in South Korea became a coronavirus ‘super spreader’

However, South Korea’s response has not been without missteps or critics.

In mid-February, before it emerged that the virus had spread rapidly among Shincheonji followers, Moon made the ill-fated prediction that the outbreak would “disappear before long”.

The Korean Medical Association – the country’s largest association of doctors – and conservative media have criticised the president for not outright banning travel from China.

Nearly 1.5 million South Koreans have signed an online petition calling for Moon’s impeachment over his handling of the outbreak, and his approval rating this week dropped to just under 45 per cent – although, in a sign of reviving fortunes, an opinion poll released on Friday saw the president’s response rated favourably.

Medical workers attend to a woman who was feeling unwell upon her arrival at the Keimyung University hospital in Daegu. Photo: AFP
Medical workers attend to a woman who was feeling unwell upon her arrival at the Keimyung University hospital in Daegu. Photo: AFP

It is still too early to say whether the response is working – Kim Dong-hyun, president of the Korean Society of Epidemiology

Some experts caution that it is too early to tell if South Korea truly has the virus under control. The discovery of a new cluster of about 100 infections at a call centre in densely populated Seoul prompted a sudden uptick in cases on Wednesday, raising fears the virus could be on the verge of spreading uncontrollably nationwide.
“It is still too early to say whether the response is working,” said Kim, the president of the Korean Society of Epidemiology. “There is an optical illusion involved in the figures. The daily numbers of new cases appear to be decreasing as the screening of Shincheonji followers is coming to an end, but it must be noted that there are new clusters emerging in Seoul and other areas. We can’t lower vigilance.”
Like elsewhere, the country is facing unknown factors such as warming temperatures in the coming weeks and the arrival of travellers from new and emerging infection hotspots overseas. “We are seeing that in South Korea, large epidemics can be slowed,” said Mackay from the University of Queensland. “Can they be prevented? That will be the challenge for countries who have yet to see widespread community transmission.”

In the face of uncertainty, South Korea appears determined to hold firm to its strategy. During a visit to the Korea Centres for Disease Control and Prevention on Wednesday, Moon said the country’s response had received international recognition and allowed it to avoid the “extreme choice” of sweeping travel bans.

The next day, responding to the World Health Organisation’s decision to declare the virus a global pandemic, the president called on South Koreans to maintain hope that the virus would be overcome.

“It might take more time than we thought,” Moon said. “Everyone, please don’t become fatigued.” 

Source: SCMP

12/03/2020

Coronavirus: China should not rely on massive stimulus to overcome ‘unprecedented’ economic slowdown

  • In response to the 2008 global financial crisis, China pumped a 4 trillion yuan (US$575 billion) into its economy but it led to a mountain of local government debt
  • Various early indicators suggest China’s economy will slow in the first quarter of 2020, with some suggestions it will suffer a first contraction since 1976
President Xi Jinping said China must accelerate construction of “new infrastructures such as 5G networks and data centres” on top of speeding up “key projects and major infrastructure construction” in response to the economic impact caused by the coronavirus outbreak. Photo: Xinhua
President Xi Jinping said China must accelerate construction of “new infrastructures such as 5G networks and data centres” on top of speeding up “key projects and major infrastructure construction” in response to the economic impact caused by the coronavirus outbreak. Photo: Xinhua

China should not try to bolster its coronavirus-hit economy by again resorting to a massive debt-fuelled fiscal and monetary stimulus programme, according to a group of government advisers.

Various early indicators suggest China’s economy will slow in the first quarter of 2020, with some even suggesting it will suffer a first contraction since the end of the Cultural Revolution in 1976.

This raises the question if China will miss its key 2020 growth target, with voices on both sides of the debate discussing what stimulus policies are needed to offset the deep impact of the coronavirus.

China is already leaning towards some additional stimulus, with Premier Li Keqiang ordering the central bank pump additional money into the banking system, while President Xi Jinping has announced the need for more spending on “new infrastructure”.

Are there other ways out for China except stimulus policies?Liu Shijin

“Are there other ways out for China except stimulus policies?” rhetorically asked Liu Shijin, who previously worked closely with Vice-Premier Liu He, the top economic aide to Xi, at the Development Research Centre, the think tank attached to the State Council.

“If it really works, why can’t Japan and the United States reach a 5 per cent growth rate?”
It is believed China will need to achieve an average 5.6 per cent growth in 2020 to achieve its goal of doubling the size of its economy from 2010, which is a key goal for

Xi to achieve his target

of creating a “comprehensively well-off” society.

China’s economy grew by 6.1 per cent in 2019, and while it was the slowest in 29 years, the US economy only grew 2.3 per cent, with Japan’s estimated to grow by 0.9 per cent.
What is gross domestic product (GDP)?
Liu Shijin, who is now a deputy head of the China Development Research Foundation and a policy adviser to the People’s Bank of China, argued that a growth rate averaging 5 per cent over the next decade is sufficient for China to meet its development goals.

Growth in 2020, though, may well be below 5 per cent given that the impact of the coronavirus is “unprecedented” and larger than both severe acute respiratory syndrome (Sars) in 2003 and the 2008 global financial crisis.

Xi said earlier this month that China must accelerate construction of “new infrastructures such as 5G networks and data centres” on top of speeding up “key projects and major infrastructure construction already included in state plans” like additional high-speed railway lines in response to the economic impact caused by the coronavirus outbreak.
But as this will mainly rely on corporate and private investment, Liu Shijin feels it will be too small to engineer a major rebound in the growth rate.
When encountering challenges, we should first push forward new reform measures to unleash growth potential. Now is the right timeLiu Shijin
“It’s a different thing compared to real [government-led] economic stabilisation,” Liu Shijin told a web seminar hosted by Peking University’s National School of Development on Wednesday.

“When encountering challenges, we should first push forward new reform measures to unleash growth potential. Now is the right time.”

Instead, to support longer-term growth, China should put its efforts into the development of its “city clusters”, which could lead to higher spending on housing construction, urban infrastructure and manufacturing, added Liu Shijin, which would increase the growth rate by up to an additional percentage point over the next decade.

China has so far refrained from the massive stimulus programme it adopted in 2008 in response to the global financial crisis, which included a 4 trillion yuan (US$575 billion) plan that pumped cheap money into government-backed projects but also created a mountain of local government debt.

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Zhang Bin, a senior researcher at the Chinese Academy of Social Sciences, said infrastructure construction will remain an important part of any plan to support growth.

“If the funding [for the 4 trillion yuan stimulus] had come solely from treasury bonds or local government bonds [rather than risky lending], there wouldn’t be so much shadow banking, unmanageable credit expansion, high leverage, implicit liabilities or financial risks,” he said.

“If the balance sheets of corporations, households and local governments can’t be repaired, it might lead to insufficient demand and a decline into a vicious [downward] cycle.”

Zhang, like Liu Shijin, is a key member of the China Finance 40 Forum, a group of state economists who advocate more structural reforms to support the Chinese economy. In particular, Zhang has set sights on reforms that would boost consumption, which accounted for 58 per cent of Chinese growth last year.

“The biggest weak link of the Chinese economy is that 200 to 300 million migrant workers can’t [legally] settle in big cities,” he said. “Only if they are able to settle in the city that China can be called a real well-off society. It will also boost the economy, lift demand for manufactured goods and unleashed consumption potential.”
Currently, most large Chinese cities only provide social services including health care and schooling to residents who have a legal permit, or hukou. Most migrant workers who come to the big cities for jobs are blocked from obtaining a hukou, meaning they have to travel back to their rural hometowns to have access to basic social services, so often do not settle in their adopted city.
In response to this idea, Xu Yuan, a professor at Peking University, called for the government to build 10 million affordable housing units annually to accommodate new urban citizens, which would address short-term economic pain and serve the nation’s long-term development.
China will release its annual growth target as well as other key goals, including the fiscal deficit ratio and local bond quota, at the National People’s Congress, although the annual parliamentary convention, previously scheduled for March 5, has been postponed, with a new date yet to be announced.
Source: SCMP
03/03/2020

Coronavirus: China orders travellers quarantined amid outbreak

A Chinese office worker wears a protective mask as she waits to take a public bus after leaving work on 2 March 2020 in Beijing, ChinaImage copyright GETTY IMAGES
Image caption Authorities are also asking overseas Chinese to reconsider travel plans

Travellers from countries with severe coronavirus outbreaks who arrive in some parts of China will have to undergo a 14-day quarantine, state media say.

Travellers from the virus hotspots of South Korea, Japan, Iran and Italy arriving in the capital will have to be isolated, a Beijing official has said.

Shanghai and Guangdong announced similar restrictions earlier.

Authorities are worried the virus might be imported back into the country.

Although most virus deaths have been in China, Monday saw nine times more new infections outside China than in.

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What do I need to know about the coronavirus?

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Shanghai said it would require new arrivals from countries with “relatively serious virus conditions” to be isolated, without naming the countries.

Authorities are also asking overseas Chinese to reconsider travel plans.

“For the sake of your family’s health and safety, please strengthen your precautions, carefully decide on your travel plans and minimise mobility,” officials in one southern Chinese province said.

China reported 125 new virus cases on Tuesday – the lowest number of new daily infections in six weeks. There were also 31 more deaths – all in Hubei province, where the virus emerged.Presentational white space

Coronavirus chart 3 March 2020
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In other developments:

  • Finance ministers from the G7 countries have said they are “ready to take action”, including fiscal measures to aid the response to the virus and support the global economy
  • The Pope, who had cancelled a Lent retreat for the first time in his papacy because he was suffering from a cold, has tested negative for the virus, Italian media report
  • South Korean President Moon Jae-in has put the country into a “state of war” and ordered all government departments to shift to a 24-hour emergency system
  • Jailed British-Iranian woman Nazanin Zaghari-Ratcliffe is in good health, Iran’s judiciary has said. She was assessed after her husband said she was showing symptoms of Covid-19
  • Japan’s Olympic minister says the Tokyo 2020 Games could be postponed until later in the year. BBC Sport is keeping track of all events that are affected
  • In the UK, where there are 39 confirmed cases, the government has warned that up to a fifth of the workforce may be off sick during the peak of a coronavirus epidemic
Media caption Julie, who lives in Singapore, was diagnosed with coronavirus and then put into isolation

How are different countries affected?

There are now almost 90,000 cases worldwide in about 70 countries, although the vast majority – just under 90% – remain in China, and most of those are in Hubei province where the virus originated late last year.

Of the nearly 8,800 cases outside China, 81% are in four countries – Iran, South Korea, Italy and Japan.

Coronavirus chart 3 March 2020

One of the countries worst affected outside China – Italy – said on Monday that the death toll there had risen by 18 to 52. There are 1,835 confirmed cases, most of them in the Lombardy and Veneto areas of the north. Nearly 150 people are said to have recovered.

However, the country is seeing a slowdown in new cases. On Monday, the authorities said there were 258 new cases of the virus – a 16% increase on the previous day – after new cases spiked by 50% on Sunday.

European coronavirus map 3 March 2020
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On Tuesday, Iran said the latest death toll from the virus was 77 – although the real figure is believed to be much higher. More than 2,300 people are said to be infected, including senior political figures. The head of Iran’s emergency medical services, Pirhossein Kolivand, was one of them, the Ilna news agency reported on Tuesday.

Some 23 MPs are also reported to have tested positive for the virus, and an official close to the Supreme Leader, Ayatollah Ali Khamenei, was reported on Monday to have died of the disease.

Health officials in the US state of Washington said on Monday that four more people had died, bringing the total there to six. They are the only deaths in the US so far. Local officials say they are buying a hotel to convert it into an isolation hospital.

On Tuesday, Ukraine confirmed its first case of coronavirus, while Portugal, Iceland, Jordan, Tunisia, Armenia, Latvia, Senegal, Morocco and Andorra confirmed their first cases on Monday.

Coronavirus global map

How deadly is Covid-19?

The WHO says the virus appears to particularly affect those over 60, and people already ill.

In the first large analysis of more than 44,000 cases from China, the death rate was 10 times higher in the very elderly compared to the middle-aged.

Most patients have only mild symptoms and the death rate appears to be between 2% and 5%, the WHO said.

By comparison, seasonal flu has an average mortality rate of about 0.1%, but is highly infectious – with up to 400,000 people dying from it each year.

Other strains of coronavirus, such as Severe Acute Respiratory Syndrome (Sars) and Middle East Respiratory Syndrome (Mers), have much higher death rates than Covid-19.

Death rates for different groups

Source: The BBC

21/01/2020

China virus fears grow as human transmission and fourth death confirmed

BEIJING (Reuters) – With millions of Asians travelling on Tuesday for the Lunar New Year holiday, authorities in China confirmed that a new virus could be spread through human contact, reporting 15 medical staff had been infected and a fourth person had died.

The chilling update on the coronavirus outbreak that began in the central city of Wuhan sent shivers through financial markets, as the World Health Organisation called a meeting for Wednesday to consider declaring an international health emergency.

By the end of Monday the number of confirmed cases in China had climbed to 291, the National Health Commission said. Some 270 were in Hubei province. Wuhan, a city of 11 million people is the provincial capital.

The outbreak was also spreading to other cities, with 15 cases in southern province of Guangdong, five in the capital Beijing and two in Shanghai.

“Information about newly reported infections suggest there may now be sustained human to human transmission,” WHO Regional Director for the Western Pacific Takeshi Kasai said in an email statement.

The scare brought back bad memories of Severe Acute Respiratory Syndrome (SARS), another coronavirus that broke out in China in 2002/2003, resulting in the death of nearly 800 people in global pandemic.

Health authorities around the world have begun to step up screening of travellers arriving from China. Two cases have already been identified in Thailand, one in Japan and one in South Korea, while the Philippines reported on Tuesday its first suspected case.

Wuhan Municipal Health Commission confirmed a fourth fatality on Tuesday, disclosing that an 89-year-old man who had underlying health issues, including heart disease, died on Jan. 19.

Chinese authorities also confirmed for the first time that the virus could spread through human contact and said 15 medical staff had been infected.

The mounting anxiety was transmitted to regional markets. China’s onshore yuan CNY= fell 0.6%, its biggest daily drop since Aug. 26, 2019, while airline and travel stocks fell across the region.

European shares also slipped on mounting concerns about the impact of the outbreak, with luxury goods firms particularly hard-hit on worries about weaker demand from Chinese consumers.

The virus can cause pneumonia, with symptoms including fever and difficulty in breathing. As those symptoms are similar to many other respiratory diseases, extra screening is needed.

AIRPORT SCREENING

The origin of the virus has yet to be identified, but the primary source is most likely animal, according to WHO. Chinese officials have linked the outbreak to a seafood market in Wuhan.

“The outbreak of a SARS-like coronavirus in Wuhan is developing into a major potential economic risk to the Asia-Pacific region now that there is medical evidence of human-to-human transmission,” said Rajiv Biswas, Asia Pacific Chief Economist for IHS Markit, in an email statement.

So far, the WHO has not recommended trade or travel restrictions but such measures could be discussed at Wednesday’s emergency meeting.

China’s National Health Commission will also give an update on the outbreak at a press briefing at 10 a.m. (0200 GMT) on Wednesday.

Foreign ministry spokesman Geng Shuang said China will attend the WHO meeting and share relevant information.

“China is willing to deepen its global cooperation and work with the international community to work together to deal with the epidemic,” Geng told reporters at a regular daily briefing.

Airport authorities in the United States as well as most Asian nations also are screening passengers from Wuhan.

Australia on Tuesday said it would screen passengers on flights from Wuhan, while Singapore announced it would quarantine individuals with pneumonia and a history of travel to Wuhan within 14 days prior to the onset of symptoms.

QUEUES FOR MASKS

Wuhan officials have been using infrared thermometers to screen passengers at airports, railway stations and other passenger terminals since Jan. 14.

Zhong Nanshan, head of the National Health Commission’s team of experts investigating the outbreak, said in footage shown by state television on Monday there was no danger of a repeat of the SARS epidemic so long as precautions were taken.

Images of long lines of people queuing to buy face masks were circulating widely on Chinese social media, where the outbreak was one of the top trending topics.

Some online vendors were limiting sales of masks and hand sanitizers as demand surged.

And Shanghai’s market regulator warned on Tuesday that it will punish speculators who hoard masks and other products used for preventing diseases, according to the Shanghai Observer – a web publication backed by a Communist Party newspaper.

Trip.com, China’s top online travel booking platform, said it would refund customers who cancel bookings in Wuhan this month, or whose travel plans are disrupted by quarantines or other regulatory efforts to prevent the spread of the virus.

Source: Reuters

20/01/2020

China confirms spread of new virus as cases surge

BEIJING (Reuters) – An outbreak of a new coronavirus in China has spread to more cities, Chinese authorities said on Monday, as the number of patients tripled and a third person died, stoking concerns about containment of the illness.

The Daxing health commission in the capital Beijing said it had confirmed two cases of coronavirus, while the southern Guangdong province’s health commission confirmed one case in Shenzhen. They mark the first cases in China beyond the central city of Wuhan where the virus first emerged.

The Wuhan Municipal Health Commission said 136 new cases of pneumonia caused by the coronavirus strain had been found in the city over the weekend, adding to 62 already known cases. A third death occurred on Saturday, the authority said in a statement.

This brings the total number of known cases worldwide to more than 200, underscoring the challenge for health authorities seeking to contain the outbreak. South Korea on Monday reported its first confirmed case of the coronavirus, a 35-year-old female Chinese national who had travelled from Wuhan, the fourth patient to be reported outside China.

Hundreds of millions of Chinese tourists will be traveling domestically and abroad during the Lunar New Year holiday period that starts later this week.

A report by London Imperial College’s MRC Centre for Global Infectious Disease Analysis estimated that by Jan. 12 there were 1,723 cases in Wuhan City with onset of related symptoms. Chinese health authorities have not commented directly on the report.

CONTAINMENT EFFORTS

Authorities around the globe, including in the United States and many Asian countries, have stepped up screening of travellers from Wuhan. Last week, two cases were reported in Thailand and one in Japan. All three involved people from Wuhan or who recently visited the city.

The virus belongs to the same family of coronaviruses as Severe Acute Respiratory Syndrome (SARS), which killed nearly 800 people globally during a 2002/03 outbreak that also started in China.

Its symptoms include fever and difficulty in breathing, which are similar to many other respiratory diseases and pose complications for screening efforts.

China’s National Health Commission said on Sunday it will step up prevention efforts, but acknowledged it still doesn’t know the source of the virus.

Shares in pharmaceutical firms and mask makers in China surged Monday because of the outbreak.

The outbreak was one of the top trending topics on Chinese social media platform Weibo, where many users expressed concerns about their safety.

“Who knows how many people who have been to Wuhan may be unaware that they have already been infected?,” one user said.

China’s Global Times, published by the ruling Communist Party’s official People’s Daily newspaper, said in an editorial the government needs to disclose all information and not repeat the mistakes made with SARS. Chinese officials covered up the SARS outbreak for weeks before a growing death toll and rumours forced it to reveal the epidemic.

“Concealment would be a serious blow to the government’s credibility and might trigger greater social panic,” the editorial said.

Source: Reuters

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