Archive for ‘six’

29/04/2020

Coronavirus: Oxford vaccine effective in monkeys, heading for mass production in India

  • Six animals inoculated with vaccine candidate then exposed to virus did not catch Covid-19 after 28 days
  • Up to 60 million doses could be produced by Serum Institute of India this year
Microbiologist Elisa Granato gets an injection on Thursday as part of the first human trials in Britain for a potential coronavirus vaccine. Photo: University of Oxford via AP
Microbiologist Elisa Granato gets an injection on Thursday as part of the first human trials in Britain for a potential coronavirus vaccine. Photo: University of Oxford via AP

A leading candidate for a Covid-19 vaccine has shown promising results in animal trials, and is expected to see mass production in India within months.

The Serum Institute of India, the world’s largest maker of vaccines by volume, said on Tuesday that it plans this year to produce up to 60 million doses of a potential vaccine developed by the University of Oxford, which is under clinical trial in Britain.

While the vaccine candidate, called “ChAdOx1 nCoV-19”, is yet to be proven to work against Covid-19, Serum decided to start manufacturing it as it had shown success in animal trials and had progressed to tests on humans, Serum Chief Executive Adar Poonawalla said.

Six rhesus macaque monkeys were inoculated with the vaccine candidate at the National Institutes of Health’s Rocky Mountain Laboratory in Montana last month, according to The New York Times.

Covid-19 vaccine trial starts in Oxford, but remdesivir treatment reportedly flops in China tests
The subjects were exposed afterwards to large quantities of the novel coronavirus, but all six remained healthy after more than 28 days, the newspaper reported, citing researcher Vincent Munster, who conducted the test.

More than 3 million people have been reported to be infected globally and over 210,000 have died from Covid-19, the respiratory disease caused by the coronavirus.

“They are a bunch of very qualified, great scientists [at Oxford] … That’s why we said we will go with this and that’s why we are confident,” Poonawalla told Reuters in a phone interview.

“Being a private limited company, not accountable to public investors or bankers, I can take a little risk and sideline some of the other commercial products and projects that I had planned in my existing facility,” Poonawalla said.

Bill Gates hopes his virus vaccine ‘manufacturing within a year’

27 Apr 2020

As many as 100 potential Covid-19 candidate vaccines are now under development by biotech and research teams around the world, and at least five of these are in preliminary testing in people in what are known as phase one clinical trials.

Poonawalla said he hoped trials of the Oxford vaccine, due to finish in about September, would be successful. Oxford scientists said last week the main focus of initial tests was to ascertain not only whether the vaccine worked but that it induced good immune responses and no unacceptable side effects.

Serum, owned by the Indian billionaire Cyrus Poonawalla, plans to make the vaccine at its two manufacturing plants in the western city of Pune, aiming to produce up to 400 million doses next year if all goes well, Poonawalla said.

“A majority of the vaccine, at least initially, would have to go to our countrymen before it goes abroad,” he said, adding that Serum would leave it to the Indian government to decide which countries would get how much of the vaccine and when.

Rhesus macaque monkeys are often used in animal testing because of their similarity to humans. Photo: AFP
Rhesus macaque monkeys are often used in animal testing because of their similarity to humans. Photo: AFP
Serum envisages a price of 1,000 rupees (US$14.70) per vaccine, but governments would give it to people without charge, he said.

He said Prime Minister Narendra Modi’s office was “very closely” involved in the vaccine production and the company is hoping the government will help foot the cost of making it.

Over roughly the next five months, Serum will spend some 300 million to 400 million rupees (US$4.4 million to US$5.9 million) on making around 3-5 million doses per month, he said. “[The government] are very happy to share some risk and fund something with us, but we haven’t really pencilled anything down yet,” Poonawalla said.

Coronavirus: clinical trial begins on third vaccine candidate in China

22 Apr 2020

Serum has also partnered with the US biotech firm Codagenix and Austria’s Themis on two other Covid-19 vaccine candidates and plans to announce a fourth alliance in a couple of weeks, he said.

Serum’s board last week also agreed to invest roughly 6 billion rupees (US$8.8 billion) on making a new manufacturing unit to solely produce coronavirus vaccines, Poonawalla said.

Source: SCMP

13/04/2020

Russian border becomes China’s frontline in fight against second virus wave

SUIFENHE, China (Reuters) – China’s northeastern border with Russia has become a frontline in the fight against a resurgence of the coronavirus epidemic as new daily cases rose to the highest in nearly six weeks – with more than 90% involving people coming from abroad.

Having largely stamped out domestic transmission of the disease, China has been slowly easing curbs on movement as it tries to get its economy back on track, but there are fears that a rise in imported cases could spark a second wave of COVID-19.

A total of 108 new coronavirus cases were reported in mainland China on Sunday, up from 99 a day earlier, marking the highest daily tally since March 5.

Imported cases accounted for a record 98. Half involved Chinese nationals returning from Russia’s Far Eastern Federal District, home to the city of Vladivostok, who re-entered China through border crossings in Heilongjiang province.

“Our little town here, we thought it was the safest place,” said a resident of the border city of Suifenhe, who only gave his surname as Zhu.

“Some Chinese citizens – they want to come back, but it’s not very sensible, what are you doing coming here for?”

The border is closed, except to Chinese nationals, and the land route through the city had become one of few options available for people trying to return home after Russia stopped flights to China except for those evacuating people.

Streets in Suifenhe were virtually empty on Sunday evening due to restrictions of movement and gatherings announced last week, when authorities took preventative measures similar to those imposed in Wuhan, the central Chinese city where the pandemic ripping round the world first emerged late last year.

The total number of confirmed cases in mainland China now stands at 82,160 as of Sunday, and at the peak of the first wave of the epidemic on Feb 12 there were over 15,000 new cases.

Though the number of daily infections across China has dropped sharply from that peak, China has seen the daily toll creep higher after hitting a trough on March 12 because of the rise in imported cases.

Chinese cities near the Russian frontier are tightening border controls and imposing stricter quarantines in response.

Suifenhe and Harbin, the capital of Heilongjiang, are now mandating 28 days of quarantine as well as nucleic acid and antibody tests for all arrivals from abroad.

In Shanghai, authorities found that 60 people who arrived on Aeroflot flight SU208 from Moscow on April 10 have the coronavirus, Zheng Jin, a spokeswoman for the Shanghai Municipal Health Commission, told a press conference on Monday.

Residents in Suifenhe said a lot of people had left the city fearing contagion, but others put their trust in authorities’ containment measures.

“I don’t need to worry,” Zhao Wei, another Suifenhe resident, told Reuters. “If there’s a local transmission, I would, but there’s not a single one. They’re all from the border, but they’ve all been sent to quarantine.”

Source: Reuters

10/04/2020

Chinese Long March-3B rocket fails during launch of Indonesian satellite

  • Malfunction happened during third stage of launch after earlier stages were completed successfully, state media says
  • Failed mission is second in less than a month after Long March-7A encountered problems after lift-off on March 16
A Long March-3B carrier rocket blasts off from the Xichang Satellite Launch Centre in Sichuan province in November. A similar launch on Thursday ended in failure. Photo: Xinhua
A Long March-3B carrier rocket blasts off from the Xichang Satellite Launch Centre in Sichuan province in November. A similar launch on Thursday ended in failure. Photo: Xinhua

China’s space programme suffered another setback on Thursday night with its second rocket launch failure in less than a month.

Officials are investigating what caused a malfunction during the third stage of the Long March-3B launch after lift-off from the Xichang Satellite Launch Centre in southwest Sichuan province at 7.46pm with an Indonesian Palapa-N1 satellite, Xinhua reported.

“The first and second stages of the rocket performed well, but the third stage malfunctioned,” the report said.

“Debris from the third stage of the rocket and the satellite fell [to the ground]. The launch mission failed.”

Debris from the failed mission rained down over Guam on Thursday night. Photo: Twitter
Debris from the failed mission rained down over Guam on Thursday night. Photo: Twitter
China’s state media did not say where the rocket landed, but the office of Guam Homeland Security and Civil Defence said “a fiery object over the Marianas sky” observed on Thursday evening was likely connected to the failed launch.
Video footage of the burning debris falling from the sky was widely circulated on social media.
The setback follows another failed launch on March 16, when China’s new Long March-7A, a three-stage, medium-lift, liquid-fuel rocket, encountered an “abnormality” minutes after lifting off from its launch site in the southern island province of Hainan.
China’s BeiDou system one satellite closer to full operation
11 Mar 2020

The satellite lost on Thursday – the Nusantara 2 – was built in China for Indonesian telecommunication companies Pasifik Satelit Nusantara and Indosat Ooredoo. It was intended to replace an older satellite to provide internet and broadcasting services in Indonesia and across the Asia-Pacific region to Australia, The Jakarta Post reported earlier this month.

It is not known if the failed launch will have an impact on other Long March-3B satellite launches planned for later in the year.

Introduced in 1996, the Long March-3B – also known as the CZ-3B or LM-3B – has been the main orbital carrier rocket of China’s space programme. It was used to carry many of the satellites that make up China’s BeiDou navigation system, with the latest addition being in March.

For that launch, engineers used parachutes to control where the rocket’s boosters would land after being discarded after lift-off so as to minimise the impact on people living below, state media reported.

The latest version of the Long March-3B entered service in 2007 and is dedicated to launching heavy communications satellites of up to 5.5 tonnes into geostationary transfer orbits.

Source: SCMP

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