Chindia Alert: You’ll be Living in their World Very Soon
aims to alert you to the threats and opportunities that China and India present. China and India require serious attention; case of ‘hidden dragon and crouching tiger’.
Without this attention, governments, businesses and, indeed, individuals may find themselves at a great disadvantage sooner rather than later.
The POSTs (front webpages) are mainly 'cuttings' from reliable sources, updated continuously.
The PAGEs (see Tabs, above) attempt to make the information more meaningful by putting some structure to the information we have researched and assembled since 2006.
Researchers conclude that the virus was circulating undetected in France in February
Findings highlight the difficulties governments face in tracing the source of coronavirus outbreaks
Researchers in France have carried out genetic analysis and found that the dominant types of the viral strains in the country did not come from China or Italy. Photo: AP
The coronavirus outbreak in France was not caused by cases imported from China, but from a locally circulating strain of unknown origin, according to a new study by French scientists at the Institut Pasteur in Paris.
Genetic analysis showed that the dominant types of the viral strains in France belonged to a clade – or group with a common ancestor – that did not come from China or Italy, the earliest hotspot in Europe.
“The French outbreak has been mainly seeded by one or several variants of this clade … we can infer that the virus was silently circulating in France in February,” said researchers led by Dr Sylvie van der Werf and Etienne Simon-Loriere in a non-peer reviewed paper released on bioRxiv.org last week.
The Covid-19 pandemic has infected more than 128,000 people in France and caused more than 23,000 deaths.
France detected the virus in late January, before any other country in Europe. A few patients with a travel history that included China’s Hubei province were sampled on January 24 and tested positive.
The Covid-19 pandemic has infected more than 128,000 people in France and caused more than 23,000 deaths. Photo: AFP
The French government took quick and decisive measures to trace contacts of the infected people and shut down the chance of further infection.
However, these strains were not found in patients tested after the initial imported cases, suggesting “the quarantine imposed on the initial Covid-19 cases in France appears to have prevented local transmission”, the researchers said.
The Pasteur institute collected samples from more than 90 other patients across France and found the strains all came from one genetic line. Strains following this unique path of evolution had so far only been detected in Europe and the Americas.
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The earliest sample in the French clade was collected on February 19 from a patient who had no history of travel and no known contact with returned travellers.
Several patients had recently travelled to other European countries, the United Arab Emirates, Madagascar and Egypt but there was no direct evidence that they contracted the disease in these destinations.
To the researchers’ surprise, some of the later strains collected were genetically older – or closer to the ancestral root – than the first sample in this clade.
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A possible explanation, according to the authors, was that local transmission had been occurring in France for some time without being detected by health authorities.
The French government may have missed detecting the transmission. According to the researchers, a large proportion of those patients might have had mild symptoms or none at all.
The researchers also found that three sequences later sampled in Algeria were closely related to those in France, suggesting that travellers from France might have introduced the virus to the African country and caused an outbreak.
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Benjamin Neuman, professor and chair of biological sciences with the Texas A&M University-Texarkana, said the French strains might have come from Belgium, where some sequences most closely related to the original strain from China were clustered.
“Since the earliest European strains of [the coronavirus] Sars-CoV-2 seem to be associated with Belgium, the idea that the virus spread from Belgium to both Italy and France at around the same time seems plausible, as this paper contends,” he said.
France is the latest in a growing number of countries and areas where no direct link between China and local outbreaks could be established.
The dominant strains in Russia and Australia, for instance, came from Europe and the United States, respectively, according to some studies.
These findings have drawn fire from some politicians who have tried to deflect domestic anger over their handling of the crisis by blaming China.
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“So now the Fake News @nytimes is tracing the CoronaVirus origins back to Europe, NOT China. This is a first!” he tweeted on April 11, referring to a story about the studies in the The New York Times’ science section.
The findings also highlight the difficulties governments face in tracing the source of coronavirus outbreaks.
Less-developed countries may never know where their strains came from due to inadequate testing and sequencing capability.
India, for example, has released the genetic sequence of fewer than 40 samples to the public so far, a small number considering its huge population.
Most of the strains sampled in 35 early cases came from clades that could be traced to Italy and Iran, with only a few from China, according to a recent study. But researchers were not able to track further because of the lack of data.
A scientist on the study, Dr Mukesh Thakur, of the Zoological Survey of India, said it was too early to rule out China as the source of outbreaks in India because the number of samples at hand was limited.
A 20-year-old student studying medicine in Wuhan, for instance, might have come in contact with many people on the way home before she was tested positive on January 30.
Thakur said local media reported that the Indian government quarantined 3,500 people possibly linked to three positive cases imported from Wuhan.
“God knows how many of them tested positive in the subsequent stages,” Thakur said in an email response to the Post’s queries on Tuesday.
Some prominent scientists, including Francis Collins, director of the US National Institutes of Health, said the virus might have been spreading quietly in humans for years, or even decades, without causing a detectable outbreak.
The virus had thus adapted well to the human body. Some genes regulating its binding to host cells were similar, or even identical, to those found in some other highly infectious human viruses, such as HIV and Ebola.
According to some estimates, the ancestor of Sars-CoV-2, the virus causing Covid-19, might have left bats between 50 and 70 years ago. A recent study by a team of geneticists in Oxford University estimated the first outbreak of the current pandemic could have occurred as early as September last year.
They found that the dominant strains circulating in China and Asia were genetically younger than some popular strains in the United States.
Company making front-runner appeals for people to take part in trial stage, which nine potential Chinese vaccines are set to enter in April
US trialling vaccine that copies virus’ genetic code, amid international search for a drug to help limit the outbreak’s human and economic impact
CanSino is recruiting healthy volunteers for a clinical trial of its vaccine candidate. Photo: Weibo
The race to develop a Covid-19 vaccine is on, with the United States already starting a clinical trial and China close behind.
On Tuesday, vaccine producer CanSino Biologics, in Tianjin in China’s northeast, said it was looking for volunteers to take part in a six-month clinical trial of a treatment it had developed jointly with the Academy of Military Medical Sciences.
“The vaccine does not contain infectious substances, is highly safe and stable, and requires only one inoculation,” the Hubei Centre for Disease Control and Prevention (CDC) said in its request for volunteers.
Its announcement came a day after the first participant began a phase I trial for an experimental vaccine funded by the US National Institutes of Health and developed by biotech startup Moderna.
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It uses messenger ribonucleic acid (mRNA) technology that copies the genetic code of the virus instead of the actual virus. To date, no mRNA vaccine has been approved for humans.
China’s own mRNA vaccine candidate, jointly developed by the Chinese Centre for Disease Control and Prevention, Tongji University and Stermina in Shanghai, is undergoing animal trials and is expected to enter the clinical phrase in mid-April.
Developed by the CanSino and the Academy of Military Medical Sciences, the vaccine is the front-runner of nine that China is developing. All are in the process of completing preclinical trial studies and will enter clinical trials in April, with some expected to advance faster than others, according to Wang Junzhi, a biological products quality control expert and academician with the Chinese Academy of Sciences.
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“China’s research and development of a vaccine for the coronavirus is, generally speaking, among the most advanced in the world,” Wang said at a press briefing in Beijing on Tuesday. “[We] will not be slower than other countries.”
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Hopes have been pinned on developing a vaccine, especially for vulnerable groups such as the elderly, in the face of an epidemic with no known cure that has brought the world to a partial standstill.
Scientists around the world are conducting experiments, and the US is reported to have tried to buy a Germany vaccine developer so that it would supply to the US only – with the German government reportedly offering its own financial incentives for the biopharmaceutical company concerned, CureVac, to stay in the country.
“A vaccine is the most effective medical means for epidemic prevention and control as it can effectively stop the spread of the virus,” Lei Chaozi, director of science and technology at China’s Ministry of Education, said.
“Vaccines also play an important part in … stabilising the economy and enabling the country to return to normal as work and production resume.”
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President Xi Jinping called for faster development of coronavirus vaccines and treatment drugs when he inspected the Academy of Military Medical Sciences two weeks ago.
About 1,000 Chinese scientists have been working on the push for vaccines, with nine vaccines developed through five different approaches, including an inactivated vaccine, a viral vector-based vaccine and a gene vaccine.
Wang said that the vaccines needed to satisfy strictly the relevant regulations and technical standards – as well as World Health Organisation requirements – before starting clinical trials.
The potential vaccine developed by CanSino and military researchers, led by virologist Chen Wei, is genetically engineered. “Spikes” on the surface of the coronavirus bind to human cells and enable the virus to invade the human cells, causing the sometimes fatal infection known as Covid-19. In theory, vaccines can rehearse such an attack and trigger the human body to be primed to respond to a real infection.
CanSino has submitted the pre-investigational new drug review application for the Ad5-nCoV vaccine to Chinese regulatory authorities, and is in the process of submitting the related technical documents.
According to the Hubei CDC, volunteers for the trial must be 18 to 60 years old with no history of coronavirus infection.
CHINDIA ALERT: You'll be living in their world, very soon 