Chindia Alert: You’ll be Living in their World Very Soon
aims to alert you to the threats and opportunities that China and India present. China and India require serious attention; case of ‘hidden dragon and crouching tiger’.
Without this attention, governments, businesses and, indeed, individuals may find themselves at a great disadvantage sooner rather than later.
The POSTs (front webpages) are mainly 'cuttings' from reliable sources, updated continuously.
The PAGEs (see Tabs, above) attempt to make the information more meaningful by putting some structure to the information we have researched and assembled since 2006.
Researchers conclude that the virus was circulating undetected in France in February
Findings highlight the difficulties governments face in tracing the source of coronavirus outbreaks
Researchers in France have carried out genetic analysis and found that the dominant types of the viral strains in the country did not come from China or Italy. Photo: AP
The coronavirus outbreak in France was not caused by cases imported from China, but from a locally circulating strain of unknown origin, according to a new study by French scientists at the Institut Pasteur in Paris.
Genetic analysis showed that the dominant types of the viral strains in France belonged to a clade – or group with a common ancestor – that did not come from China or Italy, the earliest hotspot in Europe.
“The French outbreak has been mainly seeded by one or several variants of this clade … we can infer that the virus was silently circulating in France in February,” said researchers led by Dr Sylvie van der Werf and Etienne Simon-Loriere in a non-peer reviewed paper released on bioRxiv.org last week.
The Covid-19 pandemic has infected more than 128,000 people in France and caused more than 23,000 deaths.
France detected the virus in late January, before any other country in Europe. A few patients with a travel history that included China’s Hubei province were sampled on January 24 and tested positive.
The Covid-19 pandemic has infected more than 128,000 people in France and caused more than 23,000 deaths. Photo: AFP
The French government took quick and decisive measures to trace contacts of the infected people and shut down the chance of further infection.
However, these strains were not found in patients tested after the initial imported cases, suggesting “the quarantine imposed on the initial Covid-19 cases in France appears to have prevented local transmission”, the researchers said.
The Pasteur institute collected samples from more than 90 other patients across France and found the strains all came from one genetic line. Strains following this unique path of evolution had so far only been detected in Europe and the Americas.
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The earliest sample in the French clade was collected on February 19 from a patient who had no history of travel and no known contact with returned travellers.
Several patients had recently travelled to other European countries, the United Arab Emirates, Madagascar and Egypt but there was no direct evidence that they contracted the disease in these destinations.
To the researchers’ surprise, some of the later strains collected were genetically older – or closer to the ancestral root – than the first sample in this clade.
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A possible explanation, according to the authors, was that local transmission had been occurring in France for some time without being detected by health authorities.
The French government may have missed detecting the transmission. According to the researchers, a large proportion of those patients might have had mild symptoms or none at all.
The researchers also found that three sequences later sampled in Algeria were closely related to those in France, suggesting that travellers from France might have introduced the virus to the African country and caused an outbreak.
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Benjamin Neuman, professor and chair of biological sciences with the Texas A&M University-Texarkana, said the French strains might have come from Belgium, where some sequences most closely related to the original strain from China were clustered.
“Since the earliest European strains of [the coronavirus] Sars-CoV-2 seem to be associated with Belgium, the idea that the virus spread from Belgium to both Italy and France at around the same time seems plausible, as this paper contends,” he said.
France is the latest in a growing number of countries and areas where no direct link between China and local outbreaks could be established.
The dominant strains in Russia and Australia, for instance, came from Europe and the United States, respectively, according to some studies.
These findings have drawn fire from some politicians who have tried to deflect domestic anger over their handling of the crisis by blaming China.
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“So now the Fake News @nytimes is tracing the CoronaVirus origins back to Europe, NOT China. This is a first!” he tweeted on April 11, referring to a story about the studies in the The New York Times’ science section.
The findings also highlight the difficulties governments face in tracing the source of coronavirus outbreaks.
Less-developed countries may never know where their strains came from due to inadequate testing and sequencing capability.
India, for example, has released the genetic sequence of fewer than 40 samples to the public so far, a small number considering its huge population.
Most of the strains sampled in 35 early cases came from clades that could be traced to Italy and Iran, with only a few from China, according to a recent study. But researchers were not able to track further because of the lack of data.
A scientist on the study, Dr Mukesh Thakur, of the Zoological Survey of India, said it was too early to rule out China as the source of outbreaks in India because the number of samples at hand was limited.
A 20-year-old student studying medicine in Wuhan, for instance, might have come in contact with many people on the way home before she was tested positive on January 30.
Thakur said local media reported that the Indian government quarantined 3,500 people possibly linked to three positive cases imported from Wuhan.
“God knows how many of them tested positive in the subsequent stages,” Thakur said in an email response to the Post’s queries on Tuesday.
Some prominent scientists, including Francis Collins, director of the US National Institutes of Health, said the virus might have been spreading quietly in humans for years, or even decades, without causing a detectable outbreak.
The virus had thus adapted well to the human body. Some genes regulating its binding to host cells were similar, or even identical, to those found in some other highly infectious human viruses, such as HIV and Ebola.
According to some estimates, the ancestor of Sars-CoV-2, the virus causing Covid-19, might have left bats between 50 and 70 years ago. A recent study by a team of geneticists in Oxford University estimated the first outbreak of the current pandemic could have occurred as early as September last year.
They found that the dominant strains circulating in China and Asia were genetically younger than some popular strains in the United States.
SUIFENHE, China (Reuters) – China’s northeastern border with Russia has become a frontline in the fight against a resurgence of the coronavirus epidemic as new daily cases rose to the highest in nearly six weeks – with more than 90% involving people coming from abroad.
Having largely stamped out domestic transmission of the disease, China has been slowly easing curbs on movement as it tries to get its economy back on track, but there are fears that a rise in imported cases could spark a second wave of COVID-19.
A total of 108 new coronavirus cases were reported in mainland China on Sunday, up from 99 a day earlier, marking the highest daily tally since March 5.
Imported cases accounted for a record 98. Half involved Chinese nationals returning from Russia’s Far Eastern Federal District, home to the city of Vladivostok, who re-entered China through border crossings in Heilongjiang province.
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“Our little town here, we thought it was the safest place,” said a resident of the border city of Suifenhe, who only gave his surname as Zhu.
“Some Chinese citizens – they want to come back, but it’s not very sensible, what are you doing coming here for?”
The border is closed, except to Chinese nationals, and the land route through the city had become one of few options available for people trying to return home after Russia stopped flights to China except for those evacuating people.
Streets in Suifenhe were virtually empty on Sunday evening due to restrictions of movement and gatherings announced last week, when authorities took preventative measures similar to those imposed in Wuhan, the central Chinese city where the pandemic ripping round the world first emerged late last year.
The total number of confirmed cases in mainland China now stands at 82,160 as of Sunday, and at the peak of the first wave of the epidemic on Feb 12 there were over 15,000 new cases.
Though the number of daily infections across China has dropped sharply from that peak, China has seen the daily toll creep higher after hitting a trough on March 12 because of the rise in imported cases.
Chinese cities near the Russian frontier are tightening border controls and imposing stricter quarantines in response.
Suifenhe and Harbin, the capital of Heilongjiang, are now mandating 28 days of quarantine as well as nucleic acid and antibody tests for all arrivals from abroad.
In Shanghai, authorities found that 60 people who arrived on Aeroflot flight SU208 from Moscow on April 10 have the coronavirus, Zheng Jin, a spokeswoman for the Shanghai Municipal Health Commission, told a press conference on Monday.
Residents in Suifenhe said a lot of people had left the city fearing contagion, but others put their trust in authorities’ containment measures.
“I don’t need to worry,” Zhao Wei, another Suifenhe resident, told Reuters. “If there’s a local transmission, I would, but there’s not a single one. They’re all from the border, but they’ve all been sent to quarantine.”
CHINDIA ALERT: You'll be living in their world, very soon 